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| Name | Class |
|---|---|
| Yuyu Pharma, Inc. | INDUSTRY |
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The purpose of this study is to evaluate the efficacy and safety of the ticlopidine + ginko biloba compared to clopidogrel in clopidogrel resistant patients undergoing carotid artery stent placement. The investigators hypothesized that ticlopidine + ginko biloba is superior than clopidogrel in terms of post-stent ischemic lesions in these patients without serious complications.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ticlopidine+Ginko biloba | Experimental | Switch to ticlopidine + ginko biloba |
|
| Clopidogrel | Active Comparator | Keep clopidogrel |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ticlopidine + Ginko biloba | Drug | ticlopidine hydrochloride 250mg, ginko leaf ext. 80mg, twice daily |
|
| Measure | Description | Time Frame |
|---|---|---|
| New ischemic lesion on diffusion-weighted imaging (DWI) | Presence of new ischemic lesion in the ipsilesioinal hemisphere on DWI after carotid stening | within 24 hours after carotid stenting |
| Measure | Description | Time Frame |
|---|---|---|
| Number and Volume of new ischemic lesions on DWI | within 24 hours after carotid stenting | |
| Benign and malignant microembolic signals (MES) on transcranial Doppler (TCD) | within 24 hours after carotid stenting |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Oh Young Bang, MD | Contact | 82-2-3410-3599 | neuroboy50@naver.com | |
| Suk Jae Kim, MD | Contact | 82-2-3410-1895 | sukjae.kim@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Oh Young Bang, MD | Samsung Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Oh Young Bang | Recruiting | Seoul | 135710 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30761076 | Derived | Chung JW, Kim SJ, Hwang J, Lee MJ, Lee J, Lee KY, Park MS, Sung SM, Kim KH, Jeon P, Bang OY. Comparison of Clopidogrel and Ticlopidine/Ginkgo Biloba in Patients With Clopidogrel Resistance and Carotid Stenting. Front Neurol. 2019 Jan 30;10:44. doi: 10.3389/fneur.2019.00044. eCollection 2019. |
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| ID | Term |
|---|---|
| D016893 | Carotid Stenosis |
| D000083242 | Ischemic Stroke |
| ID | Term |
|---|---|
| D002340 | Carotid Artery Diseases |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| ID | Term |
|---|---|
| D013988 | Ticlopidine |
| D000077144 | Clopidogrel |
| ID | Term |
|---|---|
| D058924 | Thienopyridines |
| D013876 | Thiophenes |
| D013457 | Sulfur Compounds |
| D009930 | Organic Chemicals |
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| Clopidogrel | Drug | clopidogrel bisulfate 97.875mg(75mg as clopidogrel) |
|
|
| Ischemic stroke or transient ischemic attack (TIA) | within 30 days after carotid stenting |
| Change of clopidogrel resistance | Change of clopidogrel resistance measured by Verify now (P2Y12) | 1 day after carotid stenting |
| Pucture site hematoma | within 30 days after carotid stenting |
| Mycocardial infarction | within 30 days after carotid stenting |
| Death | within 30 days after carotid stenting |
| Hematological abnormalities | Neutrophil <1500/uL Platelet <100,000/uL AST or ALT >120 U/L | within 30 days after carotid stenting |
| D009422 | Nervous System Diseases |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D020521 | Stroke |
| D011725 |
| Pyridines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |