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| Name | Class |
|---|---|
| Duke University | OTHER |
| University of Alabama, Tuscaloosa | OTHER |
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Psychosocial interventions are attractive options for treating chronic low back pain, and many approaches now have strong support for efficacy. However, few empirical data address whether psychosocial pain treatments work because of mechanisms specified by theory, and thus investigators know very little about HOW our treatments work. It may be that different treatments work via distinct pathways that are specific to a given treatment (single effect model), or it may be that different treatments work to the extent they all operate via key mechanisms that they share (additive effects model). Examination of specific and/or shared effects on outcomes of mechanisms will provide theoretical and empirical rationale for enhancing procedures and techniques most closely linked to strong outcomes and incorporating them into future interventions, while limiting the use of others that may be revealed as inert.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| cognitive therapy | Active Comparator | Cognitive therapy will be delivered to decrease pain interference |
|
| mindfulness training | Active Comparator | Mindfulness training will be delivered to decrease pain interference |
|
| behavior therapy | Active Comparator | Behavior therapy will be delivered to decrease pain interference |
|
| treatment as usual | Active Comparator | Subjects will engage in their usual care for low back pain. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| cognitive therapy | Behavioral |
| ||
| mindfulness training |
| Measure | Description | Time Frame |
|---|---|---|
| Pain interference | Pain interference will be assessed with Pain Interference Subscale items of the Multidimensional Pain Inventory | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Activity level | Activity level will be assessed with the General Activity subscale items of the Multidimensional Pain Inventory, and via actigraphy. | 12 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| John W Burns, PhD | Rush University Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Rush University Medical Center | Chicago | Illinois | 60612 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39226076 | Derived | Gerhart J, Burns JW, Thorn B, Jensen M, Carmody J, Keefe F. Treatment mechanism and outcome decoupling effects in cognitive therapy, mindfulness-based stress reduction, and behavior therapy for chronic pain. Pain. 2025 Feb 1;166(2):408-419. doi: 10.1097/j.pain.0000000000003374. Epub 2024 Aug 30. | |
| 38199593 | Derived |
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| ID | Term |
|---|---|
| D015928 | Cognitive Behavioral Therapy |
| D001521 | Behavior Therapy |
| D013812 | Therapeutics |
| ID | Term |
|---|---|
| D011613 | Psychotherapy |
| D004191 | Behavioral Disciplines and Activities |
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| behavioral therapy | Behavioral |
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| treatment as usual | Other |
|
| Burns JW, Jensen MP, Thorn BE, Lillis TA, Carmody J, Gerhart J, Keefe F. Cognitive Therapy, Mindfulness-Based Stress Reduction, and Behavior Therapy for the Treatment of Chronic Pain: Predictors and Moderators of Treatment Response. J Pain. 2024 Jun;25(6):104460. doi: 10.1016/j.jpain.2024.01.003. Epub 2024 Jan 8. |
| 36848061 | Derived | Burns JW, Jensen MP, Gerhart J, Thorn BE, Lillis TA, Carmody J, Keefe F. Cognitive therapy, mindfulness-based stress reduction, and behavior therapy for people with chronic low back pain: A comparative mechanisms study. J Consult Clin Psychol. 2023 Mar;91(3):171-187. doi: 10.1037/ccp0000801. Epub 2023 Feb 27. |
| 34074945 | Derived | Burns JW, Jensen MP, Thorn B, Lillis TA, Carmody J, Newman AK, Keefe F. Cognitive therapy, mindfulness-based stress reduction, and behavior therapy for the treatment of chronic pain: randomized controlled trial. Pain. 2022 Feb 1;163(2):376-389. doi: 10.1097/j.pain.0000000000002357. |