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Gestational diabetes (GDM) is defined by abnormal glucose tolerance during gestation. This complication occurs in 4-10% and is associated with fetal complications and macrosomia. In addition, women with GDM have an increased risk to develop type 2 diabetes after delivery. Despite recommendations, it is difficult to follow-up all women with GDM during the postpartum period due to high numbers of subjects that exceed usual healthcare resources. It is therefore necessary to focus clinical attention toward women at high risk of type 2 diabetes in order to set adequate preventive strategies.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Gestational diabete | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood sampling and OGTT | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Metabolic index value | The primary objective relies on Receiver Operating Characteristic (ROC) curves of metabolic index values using peripheral markers during gestation : C-Reactive Protein ultrasensitive (CRPus), malonaldehyde (MDA) and adiponectin (index = (CRP + MDA)/adiponectin) to detect an abnormal glucose tolerance at 3 months (+/- 15 days) after delivery (M3) during a 75g oral glucose tolerance test (T0>110mg/dl and/or T120 >145mg/dl). The rationale for the index relies on lower adiponectin values high CRPus levels and MDA values during insulin resistance chronic inflammatory status and oxidative stress. | 3 months after delivery (+/- 15 days) |
| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of abnormal glucose tolerance in women with GDM | 3 months (+/- 15 days) following delivery |
| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of type 2 diabetes in women with GDM. | Prevalence of women with fasting blood glucose levels > 126mg/dl at 18 months (+/- 2 months) after delivery. | 18 months (+/- 2 months) after delivery |
| Adiponectin level |
Inclusion Criteria:
Women aged over 18years old
Women with the criteria of GDM during pregnancy at 21-35 weeks of gestation (one situation):
Women with signed informed consent
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospices Civils de Lyon - Hôpital Femme-Mère-Enfant - Service de gynécologie obstétrique | Bron | 69677 | France | |||
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25890778 | Result | Honnorat D, Disse E, Millot L, Mathiotte E, Claret M, Charrie A, Drai J, Garnier L, Maurice C, Durand E, Simon C, Dupuis O, Thivolet C. Are third-trimester adipokines associated with higher metabolic risk among women with gestational diabetes? Diabetes Metab. 2015 Nov;41(5):393-400. doi: 10.1016/j.diabet.2015.03.003. Epub 2015 Apr 15. |
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| ID | Term |
|---|---|
| D016640 | Diabetes, Gestational |
| ID | Term |
|---|---|
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D003920 | Diabetes Mellitus |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| D005951 | Glucose Tolerance Test |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| 18 months (+/- 2 months) after delivery |
| CHU Clermont-Ferrand - Hôpital Gabriel Montpied - Service d'endocrinologie |
| Clermont-Ferrand |
| 63003 |
| France |
| Centre Hospitalier de Givors - Hôpital de Montgelas - Service de médicine 8 | Givors | 69700 | France |
| CHU Grenoble - Clinique d'Endocrinologie Diabétologie Nutrition | Grenoble | 38000 | France |
| Hospices Civils de Lyon - Groupement Hospitalier Sud - Service d'Endocrinologie, Diabète, Nutrition | Pierre-Bénite | 69495 | France |
| CHU Saint Etienne - Hôpital Nord - Service d'endocrinologie, diabètes, nutrition | Saint-Etienne | 42055 | France |
| Groupement Hospitalier des Portes du Sud - Service d'Endocrinologie Diabétologie Nutrition | Vénissieux | 69200 | France |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
| D001774 | Blood Chemical Analysis |
| D019963 | Clinical Chemistry Tests |
| D003940 | Diagnostic Techniques, Endocrine |