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| ID | Type | Description | Link |
|---|---|---|---|
| 2013-A01835-40 | Other Identifier | CPP Nord-Ouest III |
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| Name | Class |
|---|---|
| Centre d'Investigation Clinique et Technologique 805 | OTHER |
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Determining the optimal Neurally Adjusted Ventilatory Assist (NAVA) level remains challenging, and several methods have been suggested. However none of them seems easily utilisable. Thus the investigators propose to test a way of NAVA level titration according to ventilator comfort.
Physiological comparison of different levels of ventilator assistance during Neurally Adjusted Ventilatory Assist (NAVA) to evaluate the effect of these on tidal volume, inspiratoy activity, comfort scales.
We propose to evaluate the ability to guide the titration according the patient's comfort scale. The intensity of the breathing sensations will be evaluated using the labeled visual analog scale (Banzett Scale).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pressure Support Ventilation | Active Comparator | Device: PSV - pressure support ventilation |
|
| Neurally Adjusted Ventilatory Assist | Active Comparator | Device: Partial ventilator support with partial ventilation mode (NAVA) |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PSV - pressure support ventilation | Device | Gold standard partial ventilator support: Pressure Support Ventilation performed with Servo-i® ventilator (MAQUET,Critical Care, Sweden). Pressure support ventilator assistance to obtain a tidal volume of 6-8 ml/kg of ideal body weight. |
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of ventilatory comfort with the physiological parameters when varying the levels of pressure support and Neurally Adjusted Ventilatory Assist (NAVA) | To prove the feasibility of neurally adjusted ventilatory assist (NAVA) level titration according to the ventilatory comfort felt by the patient. The ventilatory comfort will be evaluated using the labeled visual analog scale (Banzett scale). | 24hr |
| Measure | Description | Time Frame |
|---|---|---|
| Efficiency | The efficiency will be evaluated by using minute ventilation | 24hr |
| Efficiency | The efficiency will be evaluated using arterial PCO2. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Nicolas TERZI, MD-PhD | University Hospital, Caen | Principal Investigator |
| Frédéric Lofaso, MD-PhD | University Hospital, Garches | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Caen | Recruiting | Caen | 14000 | France |
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| ID | Term |
|---|---|
| D059725 | Interactive Ventilatory Support |
| ID | Term |
|---|---|
| D012121 | Respiration, Artificial |
| D058109 | Airway Management |
| D013812 | Therapeutics |
| D012138 | Respiratory Therapy |
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| Neurally Adjusted Ventilatory Assist | Device | Partial ventilator support partial ventilation mode (NAVA) performed with Servo-i® ventilator (Maquet,Critical Care, Sweden). Different levels of neurally adjusted ventilatory assist are tested. Stepwise implementation of the NAVA level (steps of 25% ), returning to the " optimal " level between each evaluation (PSV 100%, NAVA 100%, 75%, 50%, 125%, 150%). |
|
| 24hr |