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Speckle tracking (STE) is a novel echocardiographic technique which permits calculation of myocardial velocities and deformation parameters such as strain and strain rate (SR). It is demonstrated that these parameters provide important insights into systolic and diastolic function, ischaemia, myocardial mechanics and many other pathophysiological processes of the heart. In this preliminary study, we investigated the role of STE in detection of early ventricular dysfunction in patients with Sjogren Syndrome, focusing on cardiorespiratory fitness.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sjogren | Sjogren Patients evaluated with Speckle tracking echocardiography |
| |
| Control | Controls Speckle tracking echocardiography |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Speckle tracking echocardiography | Procedure |
|
| Measure | Description | Time Frame |
|---|---|---|
| Longitudinal Myocardial Strain reduction in Sjogren Patients | Longitudinal Myocardial Strain reduction could be an early marker of cardiac dysfunction in patients with Sjogren Syndrome, significantly better than common measurement (such as ejection fraction) | Baseline, 24 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Association between 6minute-walking-test and Longitudinal strain reduction | Longitudinal strain reduction could be linked to decrease in cardiorespiratory fitness, especially in 6-minute-walking-test | baseline, 24 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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Consecutive patients enrolled from cardiovascular clinic
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Galeazzi IRCCS of Milan | Milan | Italy | Italy | |||
| Sapienza University |
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| ID | Term |
|---|---|
| D012859 | Sjogren's Syndrome |
| ID | Term |
|---|---|
| D001172 | Arthritis, Rheumatoid |
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
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| Rome |
| Italy |
| D012216 |
| Rheumatic Diseases |
| D014987 | Xerostomia |
| D012466 | Salivary Gland Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D015352 | Dry Eye Syndromes |
| D007766 | Lacrimal Apparatus Diseases |
| D005128 | Eye Diseases |
| D003240 | Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |