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The purpose of this study compares chemoradiation and sequential chemoradiation about Lung adenocarcinoma patients with postoperative in pN2 and then determines which therapeutic method is better for the patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Progression-free survival&Concurrent chemoradiotherapy | Experimental | The first day of radiotherapy given pemetrexed(Powder for Injection) 500mg/m2 + cisplatin(Powder for Injection) 75mg/m2, two cycles of chemotherapy given during radiotherapy; then continue to give two cycles of consolidation chemotherapy, 21 days as a cycle. Intensity-modulated radiation therapy(IMRT),5000cGy～6000cGy/5～6W. |
|
| Progression-free survival&sequential chemoradiotherapy | Active Comparator | Patients received adjuvant chemotherapy for four cycles,pemetrexed(Powder for Injection) 500mg/m2 + cisplatin(Powder for Injection) 75mg/m2, 21 days as a cycle.Then accept the Intensity-modulated radiation therapy(IMRT),5000cGy～6000cGy/5～6W. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| intensity-modulated radiation | Radiation | For concurrent chemoradiotherapy, the intensity-modulated radiation therapy(IMRT)will be given at the first day of therapy,total dose of 5000cGy～6000cGy/5-6 Weeks. |
| Measure | Description | Time Frame |
|---|---|---|
| progression-free survival | 01/01/2014-06/01/2016 | two and a half years |
| Measure | Description | Time Frame |
|---|---|---|
| Overall survival | 01/01/2014-01/01-2016 | two and a half years |
| Measure | Description | Time Frame |
|---|---|---|
| side-effect | 06/01/2014-06/01/2015 | one year |
Inclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hui Lin, Doctor | Contact | 8613878133622 | linhui33266@sina.com | |
| Jiao Yang, Master | Contact | 8613707872959 | yyvsyy6912@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The People's Hospital of Guangxi Zhuang Autonomous Region | Recruiting | Nanning | 530021 | China |
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| intensity-modulated radiation | Radiation | For sequential chemoradiotherapy,the intensity-modulated radiation will(IMRT) will be given when patients received adjuvant chemotherapy for four cycles,total dose of 5000cGy～6000cGy/5-6 Weeks. |
|
| ID | Term |
|---|---|
| D000077192 | Adenocarcinoma of Lung |
| ID | Term |
|---|---|
| D000230 | Adenocarcinoma |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D008175 | Lung Neoplasms |
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
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