Evaluating High Flow Humidification Therapy in Patients With Cystic Fibrosis

Evaluating High Flow Humidification Therapy in Patients With Cystic Fibrosis

This study is a single center, randomized pilot study to evaluate the clinical effectiveness of nasal high flow 20LPM humidification therapy in subjects with Cystic Fibrosis.

Inclusion Criteria:

• Confirmed diagnosis of CF
• Hospital admission for acute pulmonary exacerbation of CF (using Fuchs criteria 4/10)
• 10 years of age and older
• Subject is able to comply with the procedures scheduled in the protocol
• Signed informed consent form

Exclusion Criteria:

• Receipt of any aerosolized experimental or investigational drugs within 1 month of enrollment
• Subject had ear, nose, and throat (ENT) surgery, nasal bleeding, or nasal polyps within 6 months prior to study
• Subject is unlikely to comply with the procedures scheduled in the protocol
• Inability to give informed consent
• Subject requires supplemental oxygen
• History of obstructive sleep apnea
• History of pressure headaches requiring therapy within one month of enrollment
• Any other medical or psychological condition in which the study doctor(s) believe(s) would inhibit the individual from being an appropriate study subject.