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Slow release formulation of latanoprost is compared for safety and pressure-lowering efficacy with topically administration of commercially available latanoprost in patient with glaucoma and ocular hypertension
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| VS101 Insert Dose A | Experimental | VS101 Insert Dose A placed under the conjunctiva |
|
| VS101 Insert Dose B | Experimental | VS101 Insert Dose B placed under the conjunctiva |
|
| VS101 Insert Dose C | Experimental | VS101 Insert Dose C placed under the conjunctiva |
|
| Latanoprost 0.005% eye drops | Active Comparator | Latanoprost 0.005% eye drops administered once daily on the eye |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| VS101 Insert Dose A | Drug | Sustained release of latanoprost into the eye |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Intra-ocular pressure | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Intra-ocular pressure | Week 8 | |
| Intra-ocular pressure | 4 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Speciality Eyecare Centre | Bellevue | Washington | United States |
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| VS101 Insert Dose B |
| Drug |
Sustained release of latanoprost into the eye |
|
| VS101 Insert Dose C | Drug | Sustained release of latanoprost into the eye |
|
| Latanoprost 0.005% eye drops | Drug | Latanoprost 0.005% eye drops administered once daily on the eye |
|
| ID | Term |
|---|---|
| D005902 | Glaucoma, Open-Angle |
| D009798 | Ocular Hypertension |
| D005901 | Glaucoma |
| ID | Term |
|---|---|
| D005128 | Eye Diseases |
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| ID | Term |
|---|---|
| D000077338 | Latanoprost |
| D009883 | Ophthalmic Solutions |
| ID | Term |
|---|---|
| D011461 | Prostaglandins F, Synthetic |
| D011465 | Prostaglandins, Synthetic |
| D011453 | Prostaglandins |
| D015777 | Eicosanoids |
| D005231 | Fatty Acids, Unsaturated |
| D005227 | Fatty Acids |
| D008055 | Lipids |
| D012898 | Autacoids |
| D018836 | Inflammation Mediators |
| D001685 | Biological Factors |
| D019999 | Pharmaceutical Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |
| D045506 | Therapeutic Uses |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
| D020313 | Specialty Uses of Chemicals |
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