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Obese patients undergoing bariatric surgery warrant VTE prophylaxis because they are at high risk for developing a fatal pulmonary embolism or postthrombotic syndrome. However, a consensus does not exist on the most effective prophylactic approach.
Two regimens of prophylaxis are supposed , the 1st one is to give enoxaparin 40mg 2 hours before surgery and continued daily for 10 days after, and the 2nd one is to start 12 hours before surgery and continued in the same way like the 1st one.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ENOXAPARIN 2 HOURS BEFORE | Active Comparator | Giving 40 mg enoxaparin SQ 2 hours before surgery and daily for 10 days thereafter |
|
| Enoxaparin 40 mg 12 hours before | Active Comparator | Enoxaparin 40 mg 12 hours before surgery and once daily for 10 days thereafter |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Enoxaparin 40 mg 2 hours before arm | Drug | Enoxaparin 40 mg 2 hours before surgery |
|
| Measure | Description | Time Frame |
|---|---|---|
| Venous thrombosis and/or pulmonary embolism (PE) | To assess the venous thrombosis by compression ultrasonography and PE in suspected patients | Postoperative 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Bleeding from the surgery site , drain if any, GIT bleeding, | Bleeding from drain, GIT, or wounds are assessed clinically | postoperative 4 weeks |
| hospital stay | hospital stay in days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| mohamed e abd ellatif, phd | Contact | surg_latif@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| mohamed e abd ellatif, phd | Mansoura University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Manoura University | Recruiting | Al Mansurah | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36413425 | Derived | Amaral FC, Baptista-Silva JC, Nakano LC, Flumignan RL. Pharmacological interventions for preventing venous thromboembolism in people undergoing bariatric surgery. Cochrane Database Syst Rev. 2022 Nov 22;11(11):CD013683. doi: 10.1002/14651858.CD013683.pub2. |
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| ID | Term |
|---|---|
| D009767 | Obesity, Morbid |
| D011655 | Pulmonary Embolism |
| D006470 | Hemorrhage |
| ID | Term |
|---|---|
| D009765 | Obesity |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
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| ID | Term |
|---|---|
| D017984 | Enoxaparin |
| ID | Term |
|---|---|
| D006495 | Heparin, Low-Molecular-Weight |
| D006493 | Heparin |
| D006025 | Glycosaminoglycans |
| D011134 | Polysaccharides |
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| Enoxaparin 40 mg 12 hours before arm | Drug | Enoxaparin 40 mg 12 hours before surgery |
|
|
| 4 WEEKS |
| D009750 |
| Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D004617 | Embolism |
| D016769 | Embolism and Thrombosis |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
| D002241 |
| Carbohydrates |