The purpose of this study is to evaluate whether an Amitriptylin induced change in sleep patterns can be conditioned according to learning theory in healthy participants.

Inclusion Criteria:

• age between 18 years to 69 years
• willingness to refrain from alcohol consumption throughout the study
• regular sleeping habits
• fluent in German language
• is not dependent on driving to get to the study center
• provide written informed consent
• ability to understand the explanations and instructions given by the study physician and the investigator

Exclusion Criteria:

• Contraindications to study medication intake according to the information sheet for health professionals (Summary of medicinal Product Characteristics, SmPC) assessed by physical examination (including ECG) and medical history

  • allergies to amitriptyline hydrochloride or any of its ingredients
  • acute intoxication with alcohol, analgetics, hypnotics or any other psychotropic drug
  • urinary retention
  • delirium
  • untreated closed-angle glaucoma
  • prostatic hyperplasia
  • pyloric stenosis
  • paralytic ileus
  • suicidal thoughts
  • liver/ kidney/ pulmonary insufficiency
  • myasthenia gravis
  • hypokalemia
  • bradycardia
  • coronary heart disease, cardiac arrhythmias, long QT syndrome or other clinically relevant cardiac disorders
  • increased risk of seizures/ history of seizures
  • substance dependence syndrome/ history of substance dependence syndrome

• Allergies to ingredients of placebo or novel-tasting drink (CS)

• currently pregnant (verified by urine pregnancy test) or lactating

• patients suffering from a mental disorder as verified by the International Diagnosis Checklists (IDCL)

• patients suffering from a medical condition (assessed by the study physician)

• Concomitant medication interfering with study medication intake due to potential interactions

• participation in any other clinical trial 3 months prior to visit 1

• employee of the Sponsor or the principal investigator