Efficacy of a Depigmented Extract of Phleum in Local Allergic Rhinitis

Efficacy of a Depigmented Extract of Phleum in the Treatment of Local Allergic Rhinitis

The purpose of this study is evaluate the efficacy of a depigmented grass extract in the treatment of local allergic rhinitis.

Inclusion Criteria:

• Local allergic rhinitis with sensitization to grass pollen
• Skin prick test and serum specific IgE negative to grass pollen.
• Positive Nasal allergen provocation test (NAPT) to grass pollen and/or positive nasal specific IgE to grass pollen.
• Written informed consent

Exclusion Criteria:

• Immunological diseases
• Heart diseases that limit the use of adrenaline. For example, severe hypertension or treatment with beta-blockers.
• Treatment with beta-blockers
• Severe psychological disorders
• Severe atopic dermatitis
• FEV1 < 70% of reference value after treatment
• Hypersensitivity or intolerance to excipients and / or medication trial.
• Failure to adequately perform diagnostic tests or treatment.
• Sensitization to other allergens (perennial or seasonal) with clinical relevance for the subject and that may interfere in the evaluation of the response.
• Immunotherapy in the 5 years prior to their inclusion in the study.
• Pregnant women or at risk of pregnancy and lactating women.