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The purpose of the study is to determine how a mother's health and physical activity may influence her child's growth and development.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | No Intervention | Standard of care | |
| Intervention | Experimental | Exercise intervention from 12 week gestation until delivery |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise Intervention | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Risk of obesity in infants and children | Birth weight, body fat, and metabolism will be evaluated during the first 2 years of life. | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Maternal insulin sensitivity | Fasted blood samples will be analyzed to assess glucose and insulin. | 9 months |
| Maternal inflammation | Markers of inflammation will be investigated in fasted serum samples. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Aline Andres, Ph.D | UAMS | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Arkansas Children's Nutrition Center | Little Rock | Arkansas | 72202 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41168681 | Derived | Holmes CJ, Diniz-Sousa F, Sims CR, Jansen LT, Martinez A, Dupens A 3rd, Turner D, Edwards T, Bellando J, Massey-Swindle T, Diaz EC, Borsheim E, Andres A. The Effect of an Exercise Program on Maternal Health and Birth Outcomes in Sedentary Pregnant Participants with Obesity: Randomized Controlled Trial. Med Sci Sports Exerc. 2026 Mar 1;58(3):559-571. doi: 10.1249/MSS.0000000000003888. Epub 2025 Oct 30. | |
| 32844207 |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| 9 months |
| Derived |
| Saben JL, Sims CR, Piccolo BD, Andres A. Maternal adiposity alters the human milk metabolome: associations between nonglucose monosaccharides and infant adiposity. Am J Clin Nutr. 2020 Nov 11;112(5):1228-1239. doi: 10.1093/ajcn/nqaa216. |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |