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This project aims at evaluating the consequences of prenatal exposure to neurotoxicants (solvents, organophosphate pesticides) on the developing brain, in children aged from 10 to 12 years.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| study group (cohort PELAGIE) | Experimental | 100 children included in the cohort PELAGIE |
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| pilot group (no cohort PELAGIE) | Experimental | 10 children not included in the PELAGIE cohort to optimise MRI |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MRI | Device |
| ||
| neuropsychological assessment |
| Measure | Description | Time Frame |
|---|---|---|
| Measurement of the brain activity and its functionality | Measurement of the fractional anisotropy of the regions of interest on MRI : - with DTI (Diffusion Tensor Imaging) : DTI can be used to generate quantitative maps of the scalar (anisotropy, based on measurements of FA and mean diffusivity (MD)) or tensor (diffusivity expressed in the form of a 3x3 matrix) type. An intergroup analysis will be carried out to identify regions with FA and MD values different between exposed and non-exposed subjects. Tractography of the fibre bundles in the white matter could also be carried out, based on regions of interest extracted, for example, from high resolution morphometry or functional activation maps. The connectivity between these different regions may also be studied. | day 1 |
| Measure | Description | Time Frame |
|---|---|---|
| Measurement of the brain activity and its functionality | Measurement of the cerebral blood flow and the activation of the regions of interest on MRI with :
|
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Rennes | Rennes | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31518935 | Result | Binter AC, Bannier E, Simon G, Saint-Amour D, Ferre JC, Barillot C, Monfort C, Cordier S, Chevrier C, Pele F. Prenatal exposure to glycol ethers and motor inhibition function evaluated by functional MRI at the age of 10 to 12 years in the PELAGIE mother-child cohort. Environ Int. 2019 Dec;133(Pt A):105163. doi: 10.1016/j.envint.2019.105163. Epub 2019 Sep 11. |
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| ID | Term |
|---|---|
| D009483 | Neuropsychological Tests |
| ID | Term |
|---|---|
| D011581 | Psychological Tests |
| D004191 | Behavioral Disciplines and Activities |
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| Other |
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| day 1 |
| Results of neuropsychological tests | Correlation between the results of neuropsychological tests (subtests of the NEPSY (developmental NEuroPSYchological assessment) and the WISC-IV (Wechsler Intelligence Scale for Children version IV) tests that will evaluate motor inhibition, attention, working memory and graphomotor capacities) and MRI measurement | day 1 |