patients are treated with a 6 week-duration of antibiotic therapy :

• Rifampin IP and PO twice daily, 10mg/kg /12H
• Levofloxacin IV and PO 500-750mg once daily
• Doxycycline PO 200mg once daily
• Trimethoprim- sulfamethoxazole IV and PO 800/160mg thrice daily
• Fusidic acid PO 500mg twice daily
• Linezolid IV and PO 600mg twice daily
• Ciprofloxacin IV and PO 750to 1000mg/12h
• Cefotaxime IV 100mg/kg in three IV infusions daily
• Ceftriaxone IV,intramuscularly or subcutaneously 2g once daily
• Cefepime IV ou intra-muscularly 2g /8-12h

patients are treated with a 12 week-duration of antibiotic therapy :

• Rifampin IP and PO twice daily, 10mg/kg /12H
• Levofloxacin IV and PO 500-750mg once daily
• Doxycycline PO 200mg once daily
• Trimethoprim- sulfamethoxazole IV and PO 800/160mg thrice daily
• Fusidic acid PO 500mg twice daily
• Linezolid IV and PO 600mg twice daily
• Ciprofloxacin IV and PO 750to 1000mg/12h
• Cefotaxime IV 100mg/kg in three IV infusions daily
• Ceftriaxone IV,intramuscularly or subcutaneously 2g once daily
• Cefepime IV ou intra-muscularly 2g /8-12h

Remission was defined as the absence of any sign of infection at the initial or a contiguous site, evaluated at least one year after the end of antibiotic treatment (ie at the end of follow-up), with neither a new infectious episode nor the need for orthopedic surgery of the foot at either of these sites during the treatment and follow-up period.

number of episodes of adverse events attributable to the antibiotic treatment recorded in each group of patients.