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The study was designed to explore the effects of different sedation protocol on incidence rates of delirium and PTSD in severe patients with mechanically ventilation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Deep sedation | Experimental | Injection of 0.05~0.1mg/kg midazolam and 1~2μg/kg fentanyl,then continuous intravenous infusion 0.05mg/kg.h midazolam and1~2μg/kg.h fentanyl to maintain sedation until attaining the target level of sedation,RASS score between -5 and -3 |
|
| Deep and daily interruption of sedation | Experimental | Injection of 0.05~0.1mg/kg midazolam and 1~2μg/kg fentanyl,then continuous intravenous infusion 0.05mg/kg.h midazolam and1~2μg/kg.h fentanyl to maintain sedation until attaining the target level of sedation,RASS score between -5 and -3.and from the second day after subject was admitted in ICU, daily interruption of sedation will be taken . |
|
| Light sedation | Experimental | Injection of 0.05~0.1mg/kg midazolam and 1~2μg/kg fentanyl,then continuous intravenous infusion 0.05mg/kg.h midazolam and1~2μg/kg.h fentanyl to maintain sedation until attaining the target level of sedation,RASS score between -2 and +1. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Deep sedation(midazolam and fentanyl ) | Drug | 0.05~0.1mg/kg midazolam and 1~2μg/kg fentanyl,IV; 0.05mg/kg.h midazolam and1~2μg/kg.h fentanyl,continuous intravenous infusion ; the target level of sedation,RASS score between -5 and -3 |
| Measure | Description | Time Frame |
|---|---|---|
| The incident rate of delirium | From weaning to discharged from ICU,about 7 days. | |
| The incident rates of PTSD | 30th day and 180th day after discharged from ICU | |
| The duration of delirium | From weaning to discharged from ICU,about 7 days. |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence rate of unexpected extubation | From intubation to weaning,about 7 days | |
| Dosage of analgesics and sedatives | From intination of analgesics and sedatives to stopping drug appication,about 7 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Deep and daily interruption of sedation(midazolam and fentanyl ) | Drug | 0.05~0.1mg/kg midazolam and 1~2μg/kg fentanyl,IV; 0.05mg/kg.h midazolam and1~2μg/kg.h fentanyl continuous intravenous infusion ; The target level of sedation,RASS score between -5 and -3. Daily interruption of sedation will be taken from the second day after admitted in ICU |
|
| Light sedation(midazolam and fentanyl ) | Drug | 0.05~0.1mg/kg midazolam and 1~2μg/kg fentanyl,IV; 0.05mg/kg.h midazolam and1~2μg/kg.h fentanyl,continuous intravenous infusion ; The target level of sedation,RASS score between -2 and +1; |
|
| The duration of mechanical ventilation | From intubation to weaning,about 7days |
| Duration of ICU | From admitted to ICU to discharged from ICU,about 7 days |
| The whole hospitalization time | From admitted to hospital to discharged from hospital,about 7 days |
| Patients' death rates within ICU stay | From admitted to ICU to discharged from ICU,about 7 days |
| Patients' death rates within hospitalized stay | From admitted to hospital to discharged from hospital,about 7 days |
| The cost in ICU | From admitted to ICU to discharged from ICU,about 7 days |
| The total cost in hospital | From admitted to hospital to discharged from hospital,about 7 days |
| ID | Term |
|---|---|
| D005283 | Fentanyl |
| ID | Term |
|---|---|
| D010880 | Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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