The Psychological Effects of Different Sedation Protocol on Mechanically Ventilated Critically Ill Adults.

The Psychological Effects of Different Sedation Protocol on Mechanically Ventilated Critically Ill adults-a Prospective, Randomized and Controlled Trial

The study was designed to explore the effects of different sedation protocol on incidence rates of delirium and PTSD in severe patients with mechanically ventilation.

Inclusion Criteria:

• Written informed consent
• Critically ill adults whose expected time of mechanical ventilation is longer than 24 hours
• Aged between 18 years old to 85 years old.

Exclusion Criteria:

• Subjects with brain injury;
• History of cardiopulmonary resuscitation;
• Mental disability;
• Taken neuromuscular blocking drugs;
• Inability to exchange;
• Contraindicated to midazolam or morphine;
• Inconvenience to daily interruption