Cognition in Older Breast Cancer Survivors: Treatment Exposure, APOE and Smoking History
Cognition in Older Breast Cancer Survivors: Treatment Exposure, APOE and Smoking History
In this study,the investigators are looking to see how older women who are survivors of breast cancer and either did or did not receive chemotherapy are affected by treatment, compared to older women who have never had cancer. Thinking and memory abilities normally decrease with age and the investigators want to see if the long-term effects of cancer treatments may make these problems worse. The investigators will also look at how thinking and memory abilities of older women are affected by genetics and smoking history. Genetics and other factors may affect the brain's chemicals or structure, and may either protect against the negative effects on thinking or make someone more at risk for them.
MSK participants who previously consented to allostatic blood and saliva collection but have not yet provided any allostatic blood or saliva samples for this study, will not be asked to provide any further samples at follow-up. Participants who have consented to allostatic sample collection and provided one set of allostatic blood and saliva samples at a previous follow-up study visit will still be asked to provide a second set of samples at a later follow-up. COH participants will continue to provide allostatic blood and saliva collection as originally outlined
Inclusion Criteria:
For cancer patients, eligibility includes:
As per medical record or self-report, post-menopausal female
As per medical record or self-report, age 60 or older at recruitment
As per medical record or self-report, age 55 or older at the time of breast cancer diagnosis
As per medical record or self report, for cancers other than breast cancer or non-melanoma/basal cell skin cancer/squamous cell skin cancer:
As per medical record or self-report, 5-15 years post diagnosis of breast cancer at the time of enrollment
As per medical record or self-report, no evidence of any cancer disease
American Joint Committee on Cancer (AJCC) stages 0-III breast cancer survivor as per clinical judgment/electronic medical record (EMR)
Score of < 11 on the Blessed Orientation-Memory-Concentration Test (BOMC)
In the judgment of the consenting professional, able to communicate well enough in English through verbal and written communication to complete the study assessments and provide informed consent
For controls participants, eligibility includes:
As per medical record or self-report, post-menopausal female
As per medical record or self-report, age 60 and older at recruitment
In the judgment of the consenting professional, able to communicate well enough in English through verbal and written communication to complete the study assessments and provide informed consent
°English proficiency verified through an adapted Bidimensional acculturation scale, score of 2.5 or above. ***The scale will only be administered to participants who report also speaking a language other than English.
Score of < 11 on the Blessed Orientation-Memory-Concentration Test (BOMC)
As per self report, no history of treatment with chemotherapy
As per self report no history of cancer except non-melanoma/basal cell skin cancer squamous cell skin carcinoma
Exclusion Criteria:
For cancer patients, exclusion criteria includes:
For control participants, exclusion criteria include