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Resistance and aerobic exercise has been shown to be effective for maintenance of muscle strength in patients with neuromuscular diseases.
Exercise in CIDP and MMN is sparsely described. The aim of the study is to evaluate changes in muscle strength during high intensive resistance training and changes in maximal oxygen consumption (VO2-max) during high intensive aerobic training in patients with CIDP or MMN in maintenance therapy with subcutaneous immunoglobulin.
The hypotheses are that muscle strength and VO2-max are significantly increased during the training sessions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Run-in - Aerobic - Resistance | Experimental |
|
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| Run-in - Resistance - Aerobic | Experimental |
|
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Resistance training | Other | Participants do resistance training of selected muscle groups. Resistance are predefined from 1-repetition max (1-RM) and increased during the 12 weeks of training:
Participants trains unilateral, the opposite site serves as reference.
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in isokinetic muscle strength | Changes in isokinetic muscle strength during resistance exercise. Four muscle groups bilateral are selected. CIDP: Knee flexion/extension Elbow flexion/extension MMN: Elbow flexion/extension Wrist flexion/extension | -12, 0, 6, 12 weeks or -12, 0, 12, 18, 24 weeks |
| Changes in maximal oxygen consumption (VO2-max) | VO2-max are measured during the 12 weeks aerobic exercise session and at enrolment 12 weeks before start of exercise. VO2-max are measured while the participant running on a ergometer bicycle by accumulation of exhaled air | -12, 0, 6, 12 weeks or -12, 0, 12, 18, 24 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Medical Research Council (MRC) | -12, 0, 6, 12, 18, 24 weeks | |
| Change in Overall Disability Sum Score (ODSS) | -12, 0, 6, 12, 18, 24 weeks | |
| Change in 6-Minute Walk test |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Neurology, Aarhus University Hospital | Aarhus C | 8000 | Denmark | |||
| Department of Neurology, Rigshospitalet, Copenhagen University Hospital |
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| ID | Term |
|---|---|
| D020277 | Polyradiculoneuropathy, Chronic Inflammatory Demyelinating |
| ID | Term |
|---|---|
| D011129 | Polyradiculoneuropathy |
| D020274 | Autoimmune Diseases of the Nervous System |
| D009422 | Nervous System Diseases |
| D003711 | Demyelinating Diseases |
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| ID | Term |
|---|---|
| D055070 | Resistance Training |
| ID | Term |
|---|---|
| D005081 | Exercise Therapy |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
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|
| Aerobic training | Other | Participants train on ergometer bicycle 2 times weekly increasing during the first weeks to 3 times weekly. Workload is measured before initiation and VO2-max, heart rate and blood pressure will be measured as well. Patients train with 60-75 % of VO2-max for 30 minutes per training session. They use heart rate monitor to store data. |
|
| -12, 0, 6, 12 weeks or -12, 0, 12, 18, 24 weeks |
| Change in Quality of Life measured by The Short Form (36) Health Survey (SF-36) questionnaire | -12, 0, 6, 12, 18, 24 weeks |
| Change in Fatigue Severity Score (FSS) | -12, 0, 6, 12, 18, 24 weeks |
| Copenhagen |
| 2100 |
| Denmark |
| D011115 | Polyneuropathies |
| D010523 | Peripheral Nervous System Diseases |
| D009468 | Neuromuscular Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D005791 |
| Patient Care |
| D013812 | Therapeutics |
| D026741 | Physical Therapy Modalities |
| D064797 | Physical Conditioning, Human |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |