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| ID | Type | Description | Link |
|---|---|---|---|
| 1R34MH102478-01 | U.S. NIH Grant/Contract | View source | |
| 7R34MH102478-02 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| Northwestern University | OTHER |
| University of Iowa | OTHER |
| National Institute of Mental Health (NIMH) | NIH |
The overarching aim of this project is to develop and pilot an innovative online intervention (Share) that integrates an Individual Internet Intervention (III) and an Internet Support Group (ISG) in preventing Postpartum Major Depression (PPMD). To establish that supportive accountability is a critical component of the intervention, Share will be compared to an III alone, and an ISG without the III components.
Postpartum major depression (PPMD) occurs in approximately 7% of women in the first three months after childbirth and up to 22% of women over the first year postpartum. The impact of PPMD can be profound, including emotional distress, impairment in daily functioning and especially in caring for an infant for women as well as disturbances in infant development. The need for preventive interventions that are effective and widely accessible is clear and widely recognized.
While several psychological interventions to prevent PPMD have demonstrated efficacy, all of these interventions require women to be physically present at a treatment site at a particular time and day. There are numerous well established access barriers to traditional face-to-face psychological interventions, particularly for postpartum women facing the demands of childcare, including cost, transportation barriers, and time constraints, all of which make it impossible for the vast majority of women to participate in preventive care. The Internet offers great potential in extending mental health services to perinatal women because it directly circumvents these barriers.
Two broad classes of internet interventions have been evaluated within medicine generally, although to date there are no published evaluations of such interventions among perinatal women: Individual Internet Interventions (IIIs), which provide patients with access to web-based self-management programs, and Internet Support Groups (ISGs), which are usually centered around a discussion board or chat room. Meta-analyses suggest that IIIs are effective with acutely depressed patients when they include regular support by live coach (d=.61), but are much less effective when they are provided as a stand-alone treatment (d=.25). The enhanced efficacy of coach-supported IIIs appears to be due to the greater adherence to the intervention (e.g. more frequent usage) resulting from personal coach contact. The obvious drawbacks are cost and scalability: infrastructures for the training, oversight and payment of coaches must be implemented.
In contrast, ISGs provide a vehicle for peer support, and are very highly valued and commonly used by perinatal women. However, while adherence may be good, trials have found unmoderated ISGs to be ineffective at reducing distress and depression, Taken together, the efficacy of the IIIs and the adherence, flexibility, and potential for peer support in an ISG suggest that peers in a well-constructed ISG that encourages support and collaborative learning, could enhance adherence and outcomes of online self-management training programs. Learning these self-management skills have proven effective in face-to-face interventions to prevent depression among perinatal women.
This intervention, which we call "Share", is based upon a unique combination of two critical concepts:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Self-Directed | Active Comparator | Access to the e-health intervention (an interactive website with didactic material and interactive tools) for participants to use at their own pace for 8 weeks (Self-Directed) |
|
| Share | Experimental | Access to the same e-health intervention + an internet social networking component consisting of up to 12 other pregnant women (Share). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Share | Behavioral |
| ||
| Self-Directed |
| Measure | Description | Time Frame |
|---|---|---|
| Change in depression symptoms over time as measured by the Inventory of Depression and Anxiety Symptoms (IDAS) | Week 20 |
| Measure | Description | Time Frame |
|---|---|---|
| Usability and satisfaction based on the USE measure | Week 20 | |
| Diagnosis of Major Depressive Disorder based on the Mini International Neuropsychiatric Interview (MINI) | Week 20 | |
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Inclusion Criteria:
Women who are:
Exclusion Criteria:
Women who:
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| Name | Affiliation | Role |
|---|---|---|
| Jennifer Duffecy, PhD | University of Illinois at Chicago | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Illinois at Chicago | Chicago | Illinois | 60612 | United States | ||
| Northwestern University |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35654284 | Derived | Duffecy J, Grekin R, Long JD, Mills JA, O'Hara M. Randomized controlled trial of Sunnyside: Individual versus group-based online interventions to prevent postpartum depression. J Affect Disord. 2022 Aug 15;311:538-547. doi: 10.1016/j.jad.2022.05.123. Epub 2022 May 30. | |
| 31140443 | Derived | Duffecy J, Grekin R, Hinkel H, Gallivan N, Nelson G, O'Hara MW. A Group-Based Online Intervention to Prevent Postpartum Depression (Sunnyside): Feasibility Randomized Controlled Trial. JMIR Ment Health. 2019 May 28;6(5):e10778. doi: 10.2196/10778. |
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| ID | Term |
|---|---|
| D019052 | Depression, Postpartum |
| ID | Term |
|---|---|
| D011644 | Puerperal Disorders |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D020444 | Reimbursement, Disproportionate Share |
| ID | Term |
|---|---|
| D012051 | Reimbursement Mechanisms |
| D007349 | Insurance, Health, Reimbursement |
| D005381 | Financing, Organized |
| D004467 | Economics |
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| Site usage as measured by the number of logins to the site over the course of the intervention |
| Week 20 |
| Chicago |
| Illinois |
| United States |
| University of Iowa | Iowa City | Iowa | United States |
| D003866 | Depressive Disorder |
| D019964 | Mood Disorders |
| D001523 | Mental Disorders |
| D004472 | Health Care Economics and Organizations |