Florbetapir Calibration to the Centiloid Scale

A Multicenter, Multicountry Study to Calibrate Florbetapir (18F) PET Imaging Data to the Centiloid Scale Based on 11C-PiB

This study is designed to demonstrate the conversion of florbetapir (18F) Positron Emission Tomography (PET) Standard Uptake Value ratio (SUVr) to Centiloid units.

Inclusion Criteria:

• Cognitively Normal Subjects

  • Males or females ≥ 21 and ≤ 45 years of age
  • Mini-mental state examination (MMSE) ≥ 29

• Clinically Diagnosed AD Subject

  • Males or females ≥ 50 years of age
  • Meet clinical criteria for dementia due to probable AD
  • MMSE ≥ 16 and ≤ 26

• Possible AD Subject

  • Males or females ≥ 50 years of age
  • Meet clinical criteria for dementia due to possible AD
  • MMSE ≥ 16 and ≤ 26

• MCI Subject

  • Males or females ≥ 60 years of age with cognitive impairment (not dementia)
  • MMSE >24 and <29

• At Risk Elderly Subject

  • Cognitively normal males or females that are known ApoE4 carriers and ≥ 75 years of age
  • MMSE ≥ 27

Exclusion Criteria:

• Have had or currently have a diagnosis of neurodegenerative disorders other than AD
• Have a current serious or unstable illness that could interfere with completion of the study
• Subject has a known brain lesion, pathology or traumatic brain injury
• Have received or participated in a trial with investigational medications in the past 30 days
• Have had a radiopharmaceutical imaging or treatment procedure within 7 days of study imaging session
• Females of childbearing potential who are not surgically sterile, not refraining from sexual activity or not using reliable methods of contraception