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| ID | Type | Description | Link |
|---|---|---|---|
| R01HL110170 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Heart, Lung, and Blood Institute (NHLBI) | NIH |
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The purpose of this research study is to study blood stem cells in diabetic patients and normal patients. We would like to better understand if these cells, called endothelial precursor cells (EPCs), are not working as expected in people with diabetes. We would like to see if the function of these cells can predict the development of diabetic retinopathy.
Diabetic retinopathy is an eye disease associated with diabetes in which the cells of the retina are damaged. It can cause blurred vision, vision loss, blindness or possible bleeding in the retina. Even with current treatments, the quality of life for people with diabetic retinopathy is much reduced.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Diabetic Patients | Mild, Moderate and Severe Retinopathy |
| |
| Healthy Controls | Age and sex matched Healthy Controls |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Diabetic Patients | Other | measuring CD34 cell function in relation to diabetic retinopathy status |
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| Measure | Description | Time Frame |
|---|---|---|
| The ACE/ACE2 ratio within EPC's | Peripheral blood of 150cc, approximately 8-10 tablespoons will be collected from a vein in the arm of both diabetic and healthy control patients. | up to 216 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| The balance of the RAS (renin-angiotensin system) within EPCs | The Endo-PAT2000 will be used to obtain this measurement. This is a 15-minute office-based test where a blood-pressure cuff is placed around the arm, inflated and measurements are obtained from a small fingertip monitor | up to 216 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Photography findings | The findings from eye photographs will be collected and evaluated from both the diabetic patients and the heallthy control patients. This will be done at either the patient's yearly visit or at their 6 week follow-up visit. | up to 216 weeks |
| Fluorescein angiogram findings |
Inclusion Criteria:
Exclusion Criteria:
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Ophthalmology and Primary Care Clinics
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| Name | Affiliation | Role |
|---|---|---|
| Maria B Grant, MD | University of Alabama at Birmingham | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Alabama | Birmingham | Alabama | 35294 | United States |
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| ID | Term |
|---|---|
| D003930 | Diabetic Retinopathy |
| D003920 | Diabetes Mellitus |
| D012164 | Retinal Diseases |
| ID | Term |
|---|---|
| D005128 | Eye Diseases |
| D003925 | Diabetic Angiopathies |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| Healthy Controls | Other | measuring CD34 cell function |
|
The findings from eye photographs will be collected and evaluated from both the diabetic patients and the heallthy control patients. This will be done at either the patient's yearly visit or at their 6 week follow-up visit. |
| up to 216 weeks |
| D048909 |
| Diabetes Complications |
| D004700 | Endocrine System Diseases |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |