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| ID | Type | Description | Link |
|---|---|---|---|
| MECC-1 | Other Identifier | MECC-1 |
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The investigators aimed to evaluate the clinical results and the inflammatory response of the minimal extracorporeal circulation system (MECC) Compared with off-pump coronary revascularization (OPCABG).
This is a randomized and prospective study in 230 patients with indications for coronary surgery, with 113 patients in the OPCABG group and 117 in the MECC group. The endpoints were the clinical and biochemical results, intra-operative outcomes and the determination of 19 inflammatory circulating markers, 17 of them for the first time analyzed comparing both techniques.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Off-pump coronary artery bypass graft | Patients operated on with off-pump coronary artery bypass graft, beating heart surgery. |
| |
| Mini extracorporeal circulation bypass | Patients operated on with mini extracorporeal circulation bypass. A modified extracorporeal system. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Off-pump coronary artery bypass graft | Procedure | Patients operated with the heart beating, without heart arrest. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Clinical outcomes | Number of Participants with Adverse Events, e.g, renal failure, atrial fibrillation, acute myocardial infarct, stroke, redo surgery, death. | within the first 30 days (plus or minus 3 days) after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Determination of increase over the first 48 hours of plasma levels of 19 circulating markers of inflammatory response. | Determination of increase over the first 48 hours after the operation of plasma levels of 19 circulating markers of inflammatory response. The levels of inflammatory markers are measured in pg / mL and subsequently, the increase over the 48 hours is determined with the area under the curve. |
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Inclusion Criteria:
Exclusion Criteria:
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230 patients with indication for coronary surgery established on the basis of current published guidelines. All patients provided written consent to enter the study.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital de la Santa Creu i Sant Pau | Barcelona | Barcelona | 08026 | Spain |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31651944 | Derived | Permanyer E, Munoz-Guijosa C, Padro JM, Ginel A, Montiel J, Sanchez-Quesada JL, Vila L, Camacho M. Mini-extracorporeal circulation surgery produces less inflammation than off-pump coronary surgery. Eur J Cardiothorac Surg. 2020 Mar 1;57(3):496-503. doi: 10.1093/ejcts/ezz291. |
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| Mini extracorporeal circulation bypass | Procedure | Patients operated with a modified extracorporeal circulation system |
|
| Area Under the Concentration-Time Curve (AUC 0-48 hours) |
| Biochemical outcomes | Changes in creatine kinase levels, troponin levels, glucose, leukocytes, platelets, hemoglobin and hematocrit levels. From basal point to 48 hours time after surgery. | Within the first 30 days (plus or minus 3 days) after surgery |
| Operative results | Number of distal anastomosis. | Within the first 30 days (plus or minus 3 days) after surgery |
| Operative results | Type of grafts used. | Within the first 30 days (plus or minus 3 days) after surgery |
| Operative results | time until removal of mechanical respiratory support | Within the first 30 days (plus or minus 3 days) after surgery |
| Operative results | Time at intensive care unit (days) | Within the first 30 days (plus or minus 3 days) after surgery |
| Operative results | Total hospitalization time (days) | Within the first 30 days (plus or minus 3 days) after surgery |
| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
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| ID | Term |
|---|---|
| D047549 | Coronary Artery Bypass, Off-Pump |
| ID | Term |
|---|---|
| D001026 | Coronary Artery Bypass |
| D009204 | Myocardial Revascularization |
| D006348 | Cardiac Surgical Procedures |
| D013504 | Cardiovascular Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
| D058017 | Vascular Grafting |
| D014656 | Vascular Surgical Procedures |
| D019616 | Thoracic Surgical Procedures |
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