EMISEP : Early Spinal Cord Lesions and Late Disability in Relapsing Remitting Multiple Sclerosis Patients

EMISEP : Early Spinal Cord Lesions and Late Disability in Relapsing Remitting Multiple Sclerosis Patients

The purpose of this study is to evaluate the prognostic value of early focal lesions and early diffuse lesions on ambulatory disability progression within 5 years after clinical onset.

Prospective, multicentric study

Patients with multiple sclerosis:

Inclusion Criteria:

• Relapsing Remitting Multiple Sclerosis patients (Mac Donald 2010 criteria)
• First clinical event < 1 year
• Brain MRI > 9 lesions or/and spinal cord attack with focal lesion on spinal cord MRI
• Score Expended Disability Status Scale < 3
• Age between 18 and 40 years

Exclusion Criteria:

• Multiple Sclerosis progressive
• Patients treated with immunosuppressive therapy
• Pregnancy

Healthy volunteers:

Inclusion Criteria:

-Age between 18 and 40 years

Exclusion Criteria:

-Pregnancy