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| ID | Type | Description | Link |
|---|---|---|---|
| PHRC/12-07 |
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The purpose of this study is to evaluate the prognostic value of early focal lesions and early diffuse lesions on ambulatory disability progression within 5 years after clinical onset.
Prospective, multicentric study
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with multiple sclerosis | Experimental | 80 patients / clinical Follow-up at M0, M6, M12, M18, M24, M30, M36, M42, M48, M54 and M60 / spinal cord MRI follow-up at M0, M12, M24, M36 and M60 / brain MRI follow-up at M0, M12, M24, M36 and M60 |
|
| Healthy volunteers | Experimental | 20 healthy volunteers (stability of spinal cord imaging) / spinal cord MRI follow-up at M0 and M24 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| spinal cord MRI follow-up | Device | Evaluation : focal lesions (number, volume, localisation), atrophy, parameters from Diffusion Tensor Imaging and parameters from Magnetization Transfer Ratio |
| Measure | Description | Time Frame |
|---|---|---|
| Progressive neurological disability | Measurement by Expended Disability Status Scale | 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| Progressive ambulatory disability | Measurement by the 25-foot timed-Walked test and 6 minutes walking | 5 years |
| Progressive disability in the upper limbs | Measurement by the nine-hole peg test |
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Patients with multiple sclerosis:
Inclusion Criteria:
Exclusion Criteria:
Healthy volunteers:
Inclusion Criteria:
-Age between 18 and 40 years
Exclusion Criteria:
-Pregnancy
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| Name | Affiliation | Role |
|---|---|---|
| Gilles GE Edan | Rennes University Hospital | Principal Investigator |
| Bruno BB Brochet | University Hospital, Bordeaux | Principal Investigator |
| Thibault TM Moreau | CHU Dijon | Principal Investigator |
| Sandra SV Vukusic | Hospices civils Lyon | Principal Investigator |
| Jean JP Pelletier | AP-HM | Principal Investigator |
| Marc MD Debouverie | Central Hospital, Nancy, France | Principal Investigator |
| Bruno BS Stankoff | Pitié Salpêtrière | Principal Investigator |
| Ayman AT Tourbah | CHU de Reims | Principal Investigator |
| Jérôme JD De Seze | CHU Strasbourg | Principal Investigator |
| David DB Brassat | University Hospital, Toulouse |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Rennes | Rennes | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30300751 | Derived | Gros C, De Leener B, Badji A, Maranzano J, Eden D, Dupont SM, Talbott J, Zhuoquiong R, Liu Y, Granberg T, Ouellette R, Tachibana Y, Hori M, Kamiya K, Chougar L, Stawiarz L, Hillert J, Bannier E, Kerbrat A, Edan G, Labauge P, Callot V, Pelletier J, Audoin B, Rasoanandrianina H, Brisset JC, Valsasina P, Rocca MA, Filippi M, Bakshi R, Tauhid S, Prados F, Yiannakas M, Kearney H, Ciccarelli O, Smith S, Treaba CA, Mainero C, Lefeuvre J, Reich DS, Nair G, Auclair V, McLaren DG, Martin AR, Fehlings MG, Vahdat S, Khatibi A, Doyon J, Shepherd T, Charlson E, Narayanan S, Cohen-Adad J. Automatic segmentation of the spinal cord and intramedullary multiple sclerosis lesions with convolutional neural networks. Neuroimage. 2019 Jan 1;184:901-915. doi: 10.1016/j.neuroimage.2018.09.081. Epub 2018 Oct 6. |
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| ID | Term |
|---|---|
| D009103 | Multiple Sclerosis |
| ID | Term |
|---|---|
| D020278 | Demyelinating Autoimmune Diseases, CNS |
| D020274 | Autoimmune Diseases of the Nervous System |
| D009422 | Nervous System Diseases |
| D003711 | Demyelinating Diseases |
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| clinical follow-up | Other | Relapses, treatments, global disability,walking performance, upper limbs motor performance, sphincter disturbances and walking difficulty |
|
| brain MRI follow-up | Other |
|
| 5 years |
| Progressive urinary disability | Measurement by the questionnaire Qualiveen | 5 years |
| Progressive difficulty walking | Measurement by the Multiple Sclerosis Walking Scale 12 | 5 years |
| Principal Investigator |
| Pierre PL Labauge | University Hospital, Montpellier | Principal Investigator |
| Thibaut TM Moreau | University Hospital, Clermont-Ferrand | Principal Investigator |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |