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| ID | Type | Description | Link |
|---|---|---|---|
| 2013-A01201-44 | Other Identifier | RCB number: |
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The main objective of our study is to evaluate the diagnostic value of copeptin testing in association with troponin HS testing during pre-hospital care (ambulance care) in the treatment of patients whose pattern of use is the occurrence chest pain suggestive of ACS but not ST+.
The secondary objectives of this study are to:
A. Evaluate the diagnostic value of determination of copeptin testing in pre-hospital care in another diagnosis;
B. Assess the prognostic value of copeptin assay on vital prognosis at day 28;
C. Evaluate the kinetics of copeptin and troponin HS between initial ambulance care and arrival at the emergency department;
D. Evaluate the potential impact of copeptin testing on pre-hospital patient care;
E. Assess the economic impact of pre-hospital copeptin testing in terms of hospital stays and optimizing ambulance movements.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| The study population | The study population includes all adult patients taken in charge by the emergency ambulance services of the participating centers for non-traumatic chest pain for suspected Acute Coronary Syndrome (ACS) without ST segment elevation. Intervention: Blood work in the ambulance Intervention: Blood work upon arrival in the emergency room Intervention: Blood work at 3 hours post-arrival in the emergency room |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood work in the ambulance | Biological | Blood sample for copeptin and troponin HS testing is taken during ambulance care. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Blood troponin HS concentration (µg/L) | Day 0, in the ambulance | |
| Blood copeptin concentration (pmol/l) | Day 0, in the ambulance | |
| Final diagnosis of ACS non ST + (yes/no) | Day 28 |
| Measure | Description | Time Frame |
|---|---|---|
| Blood troponin HS concentration (µg/L) | Day 0, upon arrival in the emergency department | |
| Blood troponin HS concentration (µg/L) | Day 0, 3 hours after arrival in the emergency department | |
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Inclusion Criteria:
Exclusion Criteria:
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The study population includes all adult patients taken in charge by the emergency ambulance services of the participating centers for non-traumatic chest pain for suspected Acute Coronary Syndrome (ACS) without ST segment elevation.
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| Name | Affiliation | Role |
|---|---|---|
| Pierre-Géraud Claret, MD | Centre Hospitalier Universitaire de Nīmes | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHRU de Montpellier - Hôpital Lapeyronie | Montpellier | 34295 | France | |||
| CHRU de Nîmes - Hôpital Universitaire Carémeau |
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| Blood work upon arrival in the emergency room | Biological | Blood in drawn for copeptin and troponin HS testing upon arrival in the emergency room. |
|
| Blood work at 3 hours post-arrival in the emergency room | Biological | Blood is drawn for troponin HS testing 3 hours after the patient's arrival in the emergency room. |
|
| Mortality |
| Day 28 |
| Would you leave the patient at home if both copeptin and troponin tests were negative? | Yes/no question asked of ambulance doctors. | Day O (in the ambulance) |
| Hospital costs (€) associated with avoidable services | Day 28 |
| Distance (km) between the hospital and the patient's place of residence | Day 28 |
| Time spent by ambulance staff at the patient's place of residence | Day 0 |
| Presence/absence of another diagnosis | Day 28 |
| Number of patients taken in charge that day by ambulance staff. | Day 0 |
| Nîmes |
| 30029 |
| France |
| ID | Term |
|---|---|
| D002637 | Chest Pain |
| D003919 | Diabetes Insipidus |
| ID | Term |
|---|---|
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D010900 | Pituitary Diseases |
| D004700 | Endocrine System Diseases |
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