Does the Time Between the End of Vascular Filling and Evaluation of Its Effectiveness Modify Fluid Challenge Results in Septic Shock?

Does the Time Between the End of Vascular Filling and Evaluation of Its Effectiveness Modify Fluid Challenge Results in Septic Shock?

The main objective of this study is to evaluate in a population of patients with septic shock receiving 500 ml crystalloid over 10 minutes, the proportion of patients classified as "responders" to the fluid challenge (increase of at least 15% of ITV in aortic) at the end of vascular filling (T10) and becoming "non-responders" 20 minutes after the end of the fluid challenge (T30) and whether this proportion is greater than 10 points.

The secondary objectives of this study are :

A. To assess changes in different ultrasound parameters: E wave , E / A ratio , E / E ' in the event of vascular filling and construct a dose response curve for vascular filling.

B. To determing a threshold value for the mitral E wave velcoity that can predict a positive response to volume expansion at T10 defined by a 15% increase in the sub aortic velocity time integral (ITV) after 500 ml of crystalloids in 10 minutes.

C. To determine a threshold value for theITV at T0 that can predict a positive response to volume expansion at T10 defined by a 15% increase in the ITV after 500 ml of crystalloids in 10 minutes.

D. To evaluate the proportion of responders at T10 becoming non-responders at T20.

E. To evaluate the proportion of nonresponders at T10 and responders at T30 .

F. To estimate the proportion of patients changing status regardless of the direction of change between T10 and T30 .

Inclusion Criteria:

• The patient has given his/hers consent or the patient is in an emergency situation (commitment to obtain the consent of the patient as soon as his/her condition permits)
• Patient affiliated or beneficiary of a health insurance plan
• Patient with septic shock: proven or suspected infection associated with hypotension or lactate> 4 mmol / l or organ dysfunction. Hypotension despite fluid resuscitation of 20 to -40 ml / kg.
• Patient under controlled mechanical ventilation
• Patient requiring vascular filling according to the following criteria:
• oliguria <0.5 ml / kg / h for at least 2h
• skin mottling
• Arterial Lactate > 2 mmol / l
• SvcO2 <70% or SvO2 <65%
• Patient on noradrenaline.

Exclusion Criteria:

• The patient is has in another interventional study that might change the results of this study within the past 3 months
• The patient is under judicial protection, under tutorship or curatorship
• The patient refuses to sign the consent
• The patient is pregnant, parturient, or breastfeeding
• Valvular pathology: grade III and IV aortic or mitral insufficiency
• Non sinus electrocardiogram
• Non-echogenic patient
• Patient with any spontaneous breathing
• Moribund patient