Effects of Stress Doses of Hydrocortisone on Coagulation Dysfunction in Patients With Septic Shock

Study of Little Doses of Hydrocortisone on Coagulation Dysfunction in Patients With Septic Shock

The purpose of this study is to find out whether stress doses of hydrocortisone attenuate coagulation dysfunction in patients with septic shock. And discuss the probable mechanism by which little doses of hydrocortisone influence coagulation system in sepsis.

Patients were randomized to receive either low-dose hydrocortisone or matching placebo.Severity of coagulopathy was estimated using ISTH DIC score. We determined the complications and mortality in two groups, and analyzed the relationship between hydrocortisone and coagulopathy.

Inclusion Criteria:

• All patients(age≧18y)
• Admitted for septic shock were considered eligible if they had no life-threatening systemic disease (ASA groups 1~3)

Exclusion Criteria:

• Lactation
• Mental disorders
• Disseminated cancer
• Secondary cancers
• Inflammatory bowel disease, or diseases hindering epidural analgesia