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| Name | Class |
|---|---|
| Fundación Mutua Madrileña | OTHER |
The aim of this study is to establish a clinical score panel based on clinical, molecular and genetic parameters that allow us to stratify and obtain an early detection of patients with an increased risk of developing hepatocellular carcinoma (HCC).
Transversal study design like a "proof of concept".
Primary objective:
The main objective is try to stablish a descriptive panel (first phase of a score system) based in the conjunction or sum of several clinical and laboratory parameters (molecular and genetic factors). The aim is to detect in a fast, early and successful way those patients that presents a high risk to develop an hepatocellular carcinoma (HCC) in the future in a specific population: HIV and HCV coinfected patients. The establishment of this panel will allow clinicians set up a correct treatment decreasing the probability of liver cirrhosis and HCC.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Grupo 0 | Null or mild fibrosis | ||
| Grupo 1 | Cirrhosis | ||
| Grupo 2 | HCC diagnosis |
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| Measure | Description | Time Frame |
|---|---|---|
| Sera inflammatory markers | Inflammatory markers will be measure used a Enzyme-linked Immunosorbent Assay | 1 day (Routine visit to normal following in Infectious Disease Department) |
| Measure | Description | Time Frame |
|---|---|---|
| Sera apoptotic markers | Apoptotic markers will be evaluated through a Enzyme-linked Immunosorbent Assay | 1 day (Routine visit in disease following at Infectious Disease Department) |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluation of genetic polymorphisms distribution between study groups of relevant genes probably implicated in the disease | Genetic polymorphisms will be evaluated using Real-Time polymerase chain reaction technique | 1 day (Routine visit in normal following at Infectious Disease Department) |
Inclusion Criteria:
Exclusion Criteria:
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HIV/HCV coinfected patients from Infectious Diseases Department
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| Name | Affiliation | Role |
|---|---|---|
| Beatriz S Sastre, PhD | Fundación para la Investigación Biomédica del Hospital Ramón y Cajal | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital Ramón y Cajal | Madrid | Spain |
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Serum, plasma, white cells
| ID | Term |
|---|---|
| D000163 | Acquired Immunodeficiency Syndrome |
| D006526 | Hepatitis C |
| D006528 | Carcinoma, Hepatocellular |
| ID | Term |
|---|---|
| D015658 | HIV Infections |
| D000086982 | Blood-Borne Infections |
| D003141 | Communicable Diseases |
| D007239 | Infections |
| D015229 | Sexually Transmitted Diseases, Viral |
| D012749 | Sexually Transmitted Diseases |
| D016180 | Lentivirus Infections |
| D012192 | Retroviridae Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
| D012897 | Slow Virus Diseases |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D007153 | Immunologic Deficiency Syndromes |
| D007154 | Immune System Diseases |
| D006525 | Hepatitis, Viral, Human |
| D018178 | Flaviviridae Infections |
| D006505 | Hepatitis |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D000230 | Adenocarcinoma |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D008113 | Liver Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
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