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The aim of Prevent CardioKids is to evaluate to what extend disturbed vascular function markers are already present in children of different weight categories and whether these are age dependent. Also differences - and relationships - between vascular function measurements and plasma biomarkers between lean and overweight/obese children will be compared.
The aim of Prevent CardioKids is to evaluate to what extend disturbed vascular function markers are already present in children of different weight categories and whether these are age dependent. Also differences - and relationships - between vascular function measurements and plasma biomarkers between lean and overweight/obese children will be compared.The primary endpoint is to examine the difference in micro- and macro-vasculature characteristics in children with different weight classifications (lean; overweight; obese; extreme obese; morbid obese). Secondary endpoints are differences in lipoprotein profiles, pro-inflammatory and oral glucose tolerance profiles between different age groups, between lean and overweight/obese children and in relation with the measured micro- and macro-vasculature characteristics
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Overweight or obese children | Overweight or obese children according to the International Obesity Task Force (IOTF) criteria following the lifestyle intervention in the Centre for Overweight Adolescent and Children's Healthcare |
| |
| Lean children | Lean children according to the International Obesity Task Force (IOTF) criteria admitted at de pediatric ward for a planned surgery, for example the correction of floppy ears |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lifestyle intervention | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Vascular function measured by peripheral arterial tonometry (EndoPAT) | The primary endpoint is the difference in micro- and macrovascular characteristics, as measured by EndoPAT in lean/overweight/obese children in different age groups. | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Differences in characteristics of the microcirculation as measured via fundus photography | Differences in characteristics of the microcirculation as measured via fundus photography in overweight/obese children in different age groups, between lean and overweight/obese children in different age groups and in relation with the measured micro- and macrovascular characteristics | 1 year |
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Inclusion Criteria:
In order to be eligible to participate in the control group, a subject must meet all of the following criteria:
Exclusion Criteria:
Retarded children
Children suffering from:
Malnourished children
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Overweight or obese children according to the International Obesity Task Force (IOTF) criteria between 6-18 years old. Overweight and obese children will be recruited in the COACH program. For the control group healthy, normal weight children between 6-18 years old.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| A. Vreugdenhil, Dr. | Contact | 003143-3875284 | a.vreugdenhil@mumc.nl | |
| K. Karnebeek, Drs. | Contact | 003143-3874402 |
| Name | Affiliation | Role |
|---|---|---|
| Anita Vreugdenhil, dr. | Maastricht University Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Maastricht University Medical Center | Recruiting | Maastricht | Limburg | 6202AZ | Netherlands |
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| Label | URL |
|---|---|
| Related Info | View source |
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| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
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| Differences in characteristics of microcirculation measured via lipoprotein profiles | Differences in characteristics of the microcirculation as measured via lipoprotein profiles in overweight/obese children in different age groups, between lean and overweight/obese children in different age groups and in relation with the measured micro- and macrovascular characteristics | 1 year |
| Differences in characteristics of the microcirculation as measured via pro-inflammatory profiles | Differences in characteristics of the microcirculation as measured via pro-inflammatory profiles in overweight/obese children in different age groups, between lean and overweight/obese children in different age groups and in relation with the measured micro- and macrovascular characteristics | 1 year |