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Post thoracotomy pain syndrome still affects 50% of patients after a thoracic surgery. Pathogenesis is unclear but there is growing evidence that neuro inflammation may play a significant role. Dexamethasone is a very potent anti-inflammatory drug. The hypothesis of this study is that dexamethasone, given pre operatively, would help reduce the incidence of post thoracotomy pain syndrome 3 months after surgery, by reducing the inflammatory response, in patients undergoing elective thoracic surgery that includes thoracic epidural analgesia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| dexamethasone 10 mg | Experimental | Dexamethasone 10 mg will be given as a single-dose, pre incision, intravenously |
|
| normal saline | Placebo Comparator | Patients in this group will receive 2.5 mL of normal saline intravenously, pre-incision |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexamethasone | Drug | 10 mg (2.5 ml) |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| cytokine elevation | 24 h after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| incidence of post thoracotomy pain syndrome | 3 months after surgery | |
| incidence of post thoracotomy pain syndrome | 6 months after surgery | |
| incisional and shoulder pain |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Véronique Brulotte, MD, MSc | Contact | 514 252-3400 | 4558 | veronique.brulotte@umontreal.ca |
| Nadia Godin, nurse | Contact | 514 252-3400 | 3193 | ngodin.hmr.@ssss.gouv.qc.ca |
| Name | Affiliation | Role |
|---|---|---|
| Veronique Brulotte, MD, Msc | Maisonneuve-Rosemont Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Maisonneuve-Rosemont Hospital | Recruiting | Montreal | Quebec | H1T 4M5 | Canada |
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| ID | Term |
|---|---|
| D059350 | Chronic Pain |
| ID | Term |
|---|---|
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D003907 | Dexamethasone |
| D002123 | Calcium Dobesilate |
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D011246 | Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
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| Normal Saline | Drug | 2.5 mL normal saline |
|
|
| acute post operative period |
| Brief pain inventory questionnaire | three months after surgery |
| Brief pain inventory questionnaire | 6 months after surgery |
| Leeds Assessment of Neuropathic Signs and Symptoms questionnaire | three and six months after surgery |
| cytokine elevation | 1h after surgery |
| cytokine elevation | 48 h after surgery |
| D000072473 |
| Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013259 | Steroids, Fluorinated |
| D001557 | Benzenesulfonates |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D001190 | Arylsulfonates |
| D017739 | Arylsulfonic Acids |
| D013451 | Sulfonic Acids |
| D013456 | Sulfur Acids |
| D013457 | Sulfur Compounds |
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |