The general objective of the study is to investigate the effect of regular aerobic exercise on resting and 24-hr blood pressure levels in men and women with stage 3-4 kidney disease and hypertension.

Inclusion Criteria:

• • Non-diabetic and >18 years of age

  • Diagnosed kidney disease with associated hypertension:
  • Non-nephrotic range proteinuria at diagnosis
  • No active glomerular disease or concomitant systemic inflammatory disease (e.g. lupus)
  • Systolic blood pressure >130 and/or diastolic blood pressure >80 mm Hg (on medication)
  • An estimated glomerular filtration rate of between 60 ml/min and 15 ml/min.
  • Individuals must be able to provide informed consent
  • Perform walking exercise training on a treadmill
  • Be able to participate in a 12-week supervised exercise program.

Exclusion Criteria:

• Currently participating in a formal exercise program
• Diabetes, active glomerular disease, or systemic inflammatory disease
• Requiring dialysis
• Have an Hematocrit <27%
• Uncontrolled hypertension (>200/110mmHg)
• Peripheral vascular disease.
• An inability to understand English or give consent. Other exclusion criteria are: any contraindications to exercise testing or training as indicated by the American College of Sports Medicine guidelines such as: Unstable coronary heart disease and symptomatic heart failure, exercise capacity limited by health problems such as angina, severe arthritis, or extreme dyspnea on exertion, progressive neuromuscular disease, pulmonary disease, or having undergone a coronary revascularization within the past 6 months prior to enrollment.