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| ID | Type | Description | Link |
|---|---|---|---|
| LIgue Pulmonaire Genevoise | Other Grant/Funding Number | Ligue Pulmonaire Genevoise |
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| Name | Class |
|---|---|
| University Hospital, Geneva | OTHER |
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There is currently no good description of patients surviving an episode of acute hypercapnic respiratory failure in the ICU. For instance, the prevalence of OSA and sleep hypoventilation in a stable clinical condition is not known in this population.
This prospective cohort describes the clinical profile, predictors of readmission (followed over a year), and the prevalence of sleep-related breathing disorders (polysomnography in a stable clinical condition 3 months after ICU discharge) in patients treated for an episode of acute hypercapnic respiratory failure in the ICU.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| AHRF follow-up |
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| Measure | Description | Time Frame |
|---|---|---|
| Sleep apnea syndrome | Apnea-Hypopnea Index defined by polysomnography | at 2 month after ICU discharge |
| Sleep Hypoventilation | defined by AASM 2012 criteria with transcutaneous PtCO2 monitoring | at 2 month after ICU discharge |
| Measure | Description | Time Frame |
|---|---|---|
| Lung physiology ( obstructive or restrictive lung disease) | FEV1, VC, TLC, DLCO | at week 2 after ICU discharge |
| Inspiratory Muscle Strength | Sniff nasal maximal inspiratory pressure, Mouth inspiratory pressure |
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Inclusion Criteria:
Exclusion Criteria:
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Patients surviving an episode of acute hypercapnic respiratory failure in the ICU
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| Name | Affiliation | Role |
|---|---|---|
| Adler E Adler, M.D. | HUG | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpitaux Universitaires de Genpve | Geneva | 1211 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32561512 | Derived | Karege G, Zekry D, Allali G, Adler D, Marti C. Gait speed is associated with death or readmission among patients surviving acute hypercapnic respiratory failure. BMJ Open Respir Res. 2020 Jun;7(1):e000542. doi: 10.1136/bmjresp-2019-000542. | |
| 27973930 | Derived | Adler D, Pepin JL, Dupuis-Lozeron E, Espa-Cervena K, Merlet-Violet R, Muller H, Janssens JP, Brochard L. Comorbidities and Subgroups of Patients Surviving Severe Acute Hypercapnic Respiratory Failure in the Intensive Care Unit. Am J Respir Crit Care Med. 2017 Jul 15;196(2):200-207. doi: 10.1164/rccm.201608-1666OC. |
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| ID | Term |
|---|---|
| D012131 | Respiratory Insufficiency |
| D029424 | Pulmonary Disease, Chronic Obstructive |
| D020181 | Sleep Apnea, Obstructive |
| D006333 | Heart Failure |
| ID | Term |
|---|---|
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
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| at week 2 after ICU discharge |
| Cardiac function | Systolic and diastolic cardiac function, pulmonary hypertension | at week 2 after ICU discharge |
| Hospital and ICU readmission rate | 1 year follow-up after ICu discharge |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012891 | Sleep Apnea Syndromes |
| D001049 | Apnea |
| D020919 | Sleep Disorders, Intrinsic |
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |