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| Name | Class |
|---|---|
| Cairo University | OTHER |
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The investigators assess in this study the sensitivity of Urea and Creatinine and that of Nitrazine test in vaginal wash after injecting saline in the vagina of patients with pre-labour rupture of membranes
The aim of this study is to compare the accuracy of measuring the urea and creatinine level versus that of nitrazine test in vaginal wash of pre-labour rupture of membranes patients.Each patient with rupture of membranes will be assessed clinically and then if not in labour , patients will be divided into 2 groups, 5ml saline will be injected in the vagina of each patient in every group then the vaginal wash will be collected in a test tube. Urea and creatinine group, biochemical tests for urea and creatinine in mIU/ml to detect their presence in the wash will be done. In Nitrazine group wash will be assessed by nitrazine paper showing bluish discoloration in rupture membranes. Sensitivity of each test in diagnosed rupture of membranes will be assessed.Which means how many patients in each test show positive results in case of diagnosed case.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| urea and creatinine | Active Comparator | urea and creatinine detected in vaginal fluid wash after injecting of 5 ml saline intavaginally |
|
| Nitrazine | Active Comparator | Biochemical description of Nitrazine in the vaginal wash |
|
| saline | Active Comparator | 5ml saline will be injected in vagina of each patient in both groups within 24 hours of membrane rupture. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Urea and creatinine | Procedure | the vagina will be washed with 5ml saline, urea and creatinine will be detected biochemically in the vaginal wash. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Urea and creatinine in vaginal fluid | 5ml saline will be injected vaginally then vaginal fluid will be collected. | Within first 24 hours after rupture of membranes in third trimester |
| Measure | Description | Time Frame |
|---|---|---|
| Nitrazine test | 5ml saline is injected vaginally then vaginal fluid is collected | Within first 24 hours after rupture of membranes in third trimester |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Nesreen A Shehata, MD | Contact | 00201024150605 | nesoomar@yahoo.com |
| Name | Affiliation | Role |
|---|---|---|
| Nesreen A Shehata, MD | Beni-Suef University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nesreen Abdel Fattah Abdullah Shehata | Recruiting | Cairo | Egypt |
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| ID | Term |
|---|---|
| D014508 | Urea |
| D003404 | Creatinine |
| C013617 | nitrazine yellow |
| D012965 | Sodium Chloride |
| ID | Term |
|---|---|
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 |
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| Nitrazine | Procedure | Nitrazine detection in vaginal wash |
|
| 5ml saline | Drug | the vagina will be washed with 5ml saline and vaginal wash will be collected. |
|
| Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
| D017670 | Sodium Compounds |