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| Name | Class |
|---|---|
| University of Newcastle Upon-Tyne | OTHER |
| Maastricht University | OTHER |
| Sugar Nutrition, UK | UNKNOWN |
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Carbohydrate is stored in the body as glycogen, which is mainly found in the liver and muscle. During endurance exercise, muscle glycogen is used as fuel for the working muscles and liver glycogen is broken down to provide glucose to maintain blood glucose (sugar) levels. Both liver and muscle glycogen are important for the ability to perform intense/prolonged endurance exercise. Therefore, nutritional strategies which can maximise the availability of glycogen in muscle and liver can benefit endurance exercise capacity.
The carbohydrates typically found in sports drinks are glucose and sometimes fructose. If glucose only is ingested during exercise, then the maximum rate at which can be absorbed from the intestine into the blood stream is ~1 g/min. However, if different sources of carbohydrate (fructose) are used, which are absorbed through a different pathway, absorption of carbohydrate can be up to ~1.8 g/min. With more carbohydrate available as a fuel, this translates into an improvement in performance.
Sucrose is a naturally occurring sugar that is made up of a single glucose and single fructose molecule. Therefore, theoretically, this can use the two different pathways of absorption and also maximise carbohydrate delivery. It is not yet known however, what impact this has on our liver and muscle glycogen stores during exercise. Therefore the aim of this study is to assess whether sucrose ingestion influences liver and muscle glycogen depletion during endurance exercise.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Glucose ingestion | Active Comparator | Glucose ingestion during exercise at a rate of 1.8 g/min. |
|
| Sucrose ingestion | Experimental | Sucrose ingestion during exercise at a rate of 1.8 g/min. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Glucose ingestion | Dietary Supplement | Glucose ingestion during exercise at 1.8 g/min |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Change in liver glycogen concentration | The change in liver glycogen concentration will be determined pre-to-post 3 h of exercise using 13C magnetic resonance spectroscopy. | 3 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Plasma glucose concentration. | Plasma glucose concentrations will be determined every 30 min during 3 h of exercise. | 3 hours |
| Plasma lactate concentration | Plasma lactate concentrations will be determined every 30 min during 3 h of exercise. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Luc van Loon, PhD | Maastricht University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Northumbria University | Newcastle upon Tyne | Tyne and Wear | NE1 8ST | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26487008 | Derived | Gonzalez JT, Fuchs CJ, Smith FE, Thelwall PE, Taylor R, Stevenson EJ, Trenell MI, Cermak NM, van Loon LJ. Ingestion of glucose or sucrose prevents liver but not muscle glycogen depletion during prolonged endurance-type exercise in trained cyclists. Am J Physiol Endocrinol Metab. 2015 Dec 15;309(12):E1032-9. doi: 10.1152/ajpendo.00376.2015. Epub 2015 Oct 20. |
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| Sucrose ingestion |
| Dietary Supplement |
Sucrose ingestion during exercise at 1.8 g/min |
|
| 3 hours |
| Plasma non-esterified fatty acid concentration | Plasma non-esterified fatty acid concentrations will be determined every 30 min during 3 h of exercise. | 3 hours |
| Indirect calorimetry | Measurements of oxygen consumption, carbon dioxide production and respiratory exchange ratio through indirect calorimetry measured every 30 minutes during exercise. | 3 hours |
| Muscle glycogen concentration | The change in muscle glycogen concentration will be determined pre-to-post 3 h of exercise using 13C magnetic resonance spectroscopy. | 3 hours |
| Change in intramyocellular lipid concentration | The change in intramyocellular lipid concentration will be determined pre-to-post 3 h of exercise using 1H magnetic resonance spectroscopy. | 3 hours |