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The aim of this study is to compare the impact of two non-medicinal strategies: the breast-feeding and saccharose to measure effects in cerebral cortex during pain using near infrared spectroscopy (NIRS)
Many studies of non-medicinal treatments(saccharose and breast-feeding)show a decrease of expression of pain in newborn. However Slater and al questioned these practices due to the absence of modification of the cerebral answer measured by evoked potential.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| saccharose | Experimental | 20% saccharose |
|
| breast-feeding | Placebo Comparator | breast-feeding |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| saccharose versus breast-feeding | Procedure | saccharose versus breast-feeding |
|
| Measure | Description | Time Frame |
|---|---|---|
| Increase of the total concentration of haemoglobin | Increase of the total concentration of haemoglobin (delta HbT) measured by the spectrometer during the intravenous injection. | Measure two minutes before painful gesture, at the moment of painful gesture and 2 minutes after painful gesture. The newborn will be followed for the duration of hospital stay, an expected average of 30 to 60 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Dosage of rate salivary cortisol | Salivary cortisol sampling | before and after painful gesture |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jean-Michel ROUE | Pole de la femme, de la Mère et de l'Enfant, CHRU de Brest | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre hospitalier universitaire | Brest | 29200 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29298184 | Result | Rioualen S, Durier V, Herve D, Misery L, Sizun J, Roue JM. Cortical Pain Response of Newborn Infants to Venepuncture: A Randomized Controlled Trial Comparing Analgesic Effects of Sucrose Versus Breastfeeding. Clin J Pain. 2018 Jul;34(7):650-656. doi: 10.1097/AJP.0000000000000581. |
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| ID | Term |
|---|---|
| D001942 | Breast Feeding |
| ID | Term |
|---|---|
| D005247 | Feeding Behavior |
| D001519 | Behavior |
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