This study will test whether cardiac MRI can improve early detection of Hodgkin lymphoma associated heart disease compared to a stress echocardiogram. By doing both stress echocardiography and cardiac MRI, we will compare the ability of the two tests to detect heart disease.

Inclusion Criteria:

• Classical or nodular lymphocyte predominant HL treated at Memorial Sloan-Kettering Cancer Center.
• Age ≥ 18 years
• Treatment for HL that included mediastinal RT at initial diagnosis or relapse.
• ≥ 5 years from last HL treatment.

Exclusion Criteria:

• Primary HL diagnosis prior to 1980.
• Additional mediastinal RT or subsequent cardiotoxic systemic therapy for secondary malignant neoplasm.
• Known CAD/CHF (defined as documented myocardial infarction, cardiac revascularization, angiographic obstructive CAD, or decreased LV function [EF < 55%] during prior clinical care).
• Contraindication to MRI (i.e. pacemakers, defibrillators, or aneurysm clips, or other implanted ferromagnetic objects), gadolinium (i.e. known hypersensitivity to gadolinium, advanced renal insufficiency as defined by glomerular filtration rate <30 ml/min/1.73m^2).
• Contraindication to exercise stress testing other than the above (i.e. unstable angina or severe valvular stenosis).

MSKCC