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| ID | Type | Description | Link |
|---|---|---|---|
| 222302 | Other Grant/Funding Number | 222302 |
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Intraoperative intravenous fluid management practice varies greatly between anesthesiologists. Postoperative fluid based weight gain is associated with major morbidity. Postoperative respiratory complications are associated with increased morbidity, mortality and hospital costs. The literature shows conflicting data regarding intraoperative fluid resuscitation volume. No large-scale studies have focused on intraoperative fluid management and postoperative respiratory dysfunction.
Hypotheses:
Primary - Liberal intraoperative fluid resuscitation is associated with an increased risk of 30 day mortality Secondary - Liberal intraoperative fluid resuscitation is associated with increased likelihood of postoperative respiratory failure, pulmonary edema, reintubation, atelectasis, acute kidney injury and peri-extubation oxygen desaturation.
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| Measure | Description | Time Frame |
|---|---|---|
| Mortality | Mortality within 30 days of surgery | within 30 days after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative pulmonary complications | The incidence of a diagnosis of pneumonia, respiratory failure, atelectasis or pulmonary edema within 3 days after extubation in the operating room. Cases where these diagnoses were present on the day before surgery were not counted. | 3 days after surgery |
| Acute Kidney Injury |
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Inclusion Criteria:
Exclusion Criteria:
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All surgical patients aged 18 upwards receiving general anesthesia at Massachusetts General Hospital between January 2007 and November 2012
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| Name | Affiliation | Role |
|---|---|---|
| Matthias J Eikermann, M.D., Ph.D. | Massachusetts General Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | United States |
| Type | Date | Date Unknown |
|---|---|---|
| Release | Apr 28, 2018 | |
| Reset | Dec 3, 2018 | |
| Release | Dec 12, 2018 |
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A Creatinine increase of >0.3mg/dl or 50% from baseline (Creatinine value closest recorded to surgery but within 30 days of surgery) to maximum value measured within 48 hours postoperatively or an ICD-9 diagnosis of AKI within 7 days of surgery but not within 30 days prior to surgery |
| within 48 hours of surgery |
| Post-extubation oxygen desaturation | One or more minutes with a blood oxygen saturation below 90% during the first ten minutes after extubation | within the first 10 minutes after extubation |
| Reset | Mar 20, 2019 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Apr 28, 2018 | Dec 3, 2018 | |||
| Dec 12, 2018 | Mar 20, 2019 |
| ID | Term |
|---|---|
| D012131 | Respiratory Insufficiency |
| D011654 | Pulmonary Edema |
| D011014 | Pneumonia |
| D000860 | Hypoxia |
| D058186 | Acute Kidney Injury |
| ID | Term |
|---|---|
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D008171 | Lung Diseases |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
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