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To compare the effect of two different agents deksmedetomidine, remifentanil and placebo, agitation and recovery condition, on nasal septum operation.
Nasal septum operation cause agitation because of nasal package. This research aims determine which agent , deksmedetomidine remifentanil or placebo, is more beneficial to the patient.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Deksmedetomidine infusion | Active Comparator | To prevent agitation deksmedetomidine infused during operation and at the end of surgery agitation scor measured by Riker sedation agitation scale. |
|
| Remifentanil infusion | Experimental | To prevent agitation remifentanil infused during operation at the end of surgery agitation scor measured by Riker sedation agitation scale. |
|
| Saline infusion | Placebo Comparator | Saline infused during operation and at the end of surgery agitation scor measured by Riker sedation agitation scale. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| deksmedetomidine | Drug | deksmedetomidine infused during operation 0.2 mcg/kg/hour |
|
| Measure | Description | Time Frame |
|---|---|---|
| To asses postoperative agitation score by Riker sedation agitation scale | Postoperative first hour |
| Measure | Description | Time Frame |
|---|---|---|
| Yo asses postoperative side effects emesis, vomitting or pain | Postoperative first hour |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Reyhan Polat, MD | Contact | +905326734310 | reyhanp9@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Reyhan Polat, MD | Yildirim Beyazit Education and Research Hospita | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Reyhan Polat | Ankara | 06610 | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D011595 | Psychomotor Agitation |
| ID | Term |
|---|---|
| D020820 | Dyskinesias |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D011596 | Psychomotor Disorders |
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| ID | Term |
|---|---|
| D020927 | Dexmedetomidine |
| D000077208 | Remifentanil |
| D012965 | Sodium Chloride |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| Remifentanil | Drug | Remifentanil infused during operation 0.2 mcg/kg/min |
|
|
| Saline | Drug | During operation saline infused equal volüme of deksmedetomidine and remifentanil |
|
| D019954 |
| Neurobehavioral Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D000096762 | Aberrant Motor Behavior in Dementia |
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
| D011422 |
| Propionates |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
| D010880 | Piperidines |
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
| D017670 | Sodium Compounds |