Observational Study of Biomarker During Liver Surgery

Autophagy in Liver Injury: Changes in Autophagy Biomarkers During Liver Surgery

The investigators would like to study whether Sirtuin 1 (SIRT1) plays a cytoprotective role in liver ischemia/reperfusion, and ultimately to develop therapeutic strategies to improve hepatic function of patients with liver diseases.

If asked to participate in this research study, it is because a liver resection/liver transplantation surgery has been scheduled. During the procedure a small section will be collected for additional testing of Sirtuin 1. In addition, information concerning the liver disease, laboratory and pathology results after surgery will be collected by the investigators.

Inclusion Criteria:

• liver resection > 2 segments,
• plate count > 100 x 109/L, and
• prothrombin activity >60%.

Exclusion Criteria:

• liver cirrhosis,
• portal hypertension,
• steatohepatitis or severe steatosis,
• patients receiving additional ablation therapies,
• laparoscopic resection, and
• simultaneous extrahepatic procedures such as colorectal resection or pancreatoduodenectomy