Effects of Antioxidant Dentifrice on Gingivitis

Clinical Study of an Ascorbic Acid Derivative Dentifrice in Patients With Gingivitis

The purpose of this study is to investigate the effect of a dentifrice containing L-ascorbic acid 2-phosphate magnesium salt on gingival inflammation, gingival bleeding and gingival redness.

Inclusion Criteria:

• Age between ≥ 20 and < 65 y with at least 16 permanent teeth.
• Gingival inflammation or mean baseline GI ≥ 0.5 without severe periodontal disease enough to require professional therapy.
• Written informed consent to participate.

Exclusion Criteria:

• Taking medications that could influence periodontal tissue health, such as antimicrobials and antihypertensives within 1 month before starting the trial.
• Use of orthodontic appliances.
• Pregnancy or planning to become pregnant during the trial period.
• Previous participation in any other clinical trial.
• Inability of patient to understand the study purpose and/or study protocols.
• Judged unsuitable by investigators for other reasons.