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| Name | Class |
|---|---|
| Osaka University | OTHER |
| Tohoku University | OTHER |
| Nihon University | OTHER |
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The purpose of this study is to investigate the effect of a dentifrice containing L-ascorbic acid 2-phosphate magnesium salt on gingival inflammation, gingival bleeding and gingival redness.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental toothpaste | Active Comparator | L-ascorbic acid 2-phosphate magnesium salt / fluoride |
|
| Control toothpaste | Placebo Comparator | fluoride |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Experimental toothpaste | Drug | Experimental toothpaste was containing 0.3% L-ascorbic acid 2-phosphate magnesium salt and 950 ppm fluoride. The registered participants were instructed to brush their teeth twice a day in their customary manner. |
| Measure | Description | Time Frame |
|---|---|---|
| Gingival Index | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Gingivitis Severity Inedex | 3 months | |
| Gingival Redness | Gingival redness was measured as an indicator of the degree of local chromatic changes in the gingiva. | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| salivary antioxidant status | Salivary antioxidant status was assessed by the ferric reduction ability of plasma (FRAP). | 3 months |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Shinya Murakami | Osaka University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nihon University Hospital, School of Dentistry at Matsudo | Matsudo | Chiba | 271-8587 | Japan | ||
| Tohoku University Dental Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25277459 | Derived | Shimabukuro Y, Nakayama Y, Ogata Y, Tamazawa K, Shimauchi H, Nishida T, Ito K, Chikazawa T, Kataoka S, Murakami S. Effects of an ascorbic acid-derivative dentifrice in patients with gingivitis: a double-masked, randomized, controlled clinical trial. J Periodontol. 2015 Jan;86(1):27-35. doi: 10.1902/jop.2014.140138. |
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| ID | Term |
|---|---|
| D005891 | Gingivitis |
| ID | Term |
|---|---|
| D007239 | Infections |
| D005882 | Gingival Diseases |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
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| Control toothpaste | Drug | Control toothpaste was containing 950 ppm fluoride. The registered participants were instructed to brush their teeth twice a day in their customary manner. |
|
|
| Sendai |
| Miyagi |
| 980-8575 |
| Japan |
| Osaka University Dental Hospital | Suita | Osaka | 565-0871 | Japan |
| Nihon University Dental Hospital | Chiyoda-ku | Tokyo | 101-8310 | Japan |
| D009057 |
| Stomatognathic Diseases |