A Phase Iv Trial To Assess The Effectiveness Of Apixaban Compared With Usual Care Anticoagulation In Subjects With Non-valvular Atrial Fibrillation Undergoing Cardioversion
A Phase Iv Trial To Assess The Effectiveness Of Apixaban Compared With Usual Care Anticoagulation In Subjects With Non-valvular Atrial Fibrillation Undergoing Cardioversion
Some people can develop an abnormal heart beat known as "Atrial fibrillation" or "AF" that puts them at risk of developing clots in the heart. Those clots can travel in the blood circulation to the brain and cause a brain attack ("a stroke"). To prevent those clots forming, blood thinners (anti-coagulants) are used. Apixaban is a blood thinner that works by stopping one of the blood substances required for clotting ("Factor Xa"). It is approved and used to prevent clots forming in people with "AF". Other established blood thinners work by stopping clotting substances being made, known as "Vitamin K antagonists" or "VKAs". An example of this type is Warfarin (Coumadin). The good effects of all blood thinners are preventing clots, and they may also have bad effects of increasing the chance of bleeding. People with "AF", abnormal heart beat, may benefit from changing it back to a normal regular rhythm, known medically as "cardioversion". When this is done, people are currently most commonly treated with a "VKA" blood thinner (e.g. warfarin). The purpose of this study is to assess the good and bad effects ("efficacy" and "safety") of apixaban compared with warfarin in people with "AF" in whom an early cardioversion is planned.
Inclusion Criteria:
Exclusion Criteria:
Chicago, Illinois 60637, United States
Chicago, Illinois 60637, United States
Lexington, Kentucky 40536-0200, United States
Lexington, Kentucky 40536, United States
Worcester, Massachusetts 01655, United States
Columbia, Missouri 65212, United States
New Brunswick, New Jersey 08901, United States
Midlothian, Virginia 23114, United States
Montreal, Quebec H1T 1C8, Canada
Berlin, 10117, Germany
Dresden, 01099, Germany
Hamburg, 20246, Germany
Acquaviva Delle Fonti (BA), BARI 70021, Italy
Torrette Di Ancona, The Marches 60020, Italy
Meguro-ku, Tokyo 153-8515, Japan
Bucharest, 022328, Romania
Deagu, 705703, South Korea
Stockholm, Södermanland County, Sweden