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The proposed project will evaluate two methods of implementation of the new Physical Activity Guidelines (PAGs) for Adults with Multiple Sclerosis (MS) living in two Ontario communities. The investigators will also determine if following the PAGs will improve aspects of fitness, function, quality of life and risk for cardiometabolic disease in this population. The investigators hypothesize that adherence to the PAGs will be higher in people who have been referred directly to a community-based exercise program, and that this greater adherence to physical activity will be associated with greater improvements in fitness, function and quality of life.
This randomized controlled trial will provide important information on how best to implement physical activity recommendations within the community setting; this information will be translated to key stakeholders during the final stages of the project.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Direct Referral to Physical Activity | Experimental | The REF group will be referred to a centre-based community exercise program in their respective community (either the MacWheelers or Revved Up) by a clinical neurologist where they will be prescribed exercise based on the PAGs for adults with MS, and according to their individual capabilities. |
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| Control | No Intervention | The CON group will be provided with a print copy of the PAGs and a link to an online resource for physical activity information. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Direct Referral to physical activity | Other | Participants randomized to the Direct Referral to Physical Activity Arm will be provided with a referral to a physical activity program in their community and will be closely monitored in this program for 16 wks. |
| Measure | Description | Time Frame |
|---|---|---|
| Adherence to the Physical Activity Guidelines | Adherence to the physical activity guidelines will be analyzed by having participants fill in a weekly physical activity log that will be sent to them by email. | 3 years |
| Measure | Description | Time Frame |
|---|---|---|
| Physical Fitness | Peak oxygen uptake, maximum muscle strength, bodyweight | At baseline and after the 16 week intervention |
| Perceived Quality of Life | Multiple Sclerosis Quality of Life (MSQoL) scale |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Audrey L Hicks, Ph.D. | McMaster University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| McMaster University, Physical Activity Centre for Excellence | Hamilton | Ontario | L8S 4K1 | Canada | ||
| Queens University |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31675636 | Derived | Canning KL, Hicks AL. Physician referral improves adherence to the physical activity guidelines for adults with MS: A randomized controlled trial. Mult Scler Relat Disord. 2020 Jan;37:101441. doi: 10.1016/j.msard.2019.101441. Epub 2019 Oct 22. |
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| ID | Term |
|---|---|
| D009103 | Multiple Sclerosis |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D020278 | Demyelinating Autoimmune Diseases, CNS |
| D020274 | Autoimmune Diseases of the Nervous System |
| D009422 | Nervous System Diseases |
| D003711 | Demyelinating Diseases |
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| At baseline and after the 16 week intervention |
| Fatigue | Multiple Sclerosis Fatigue Impact Scale (MSFIS) | At baseline and after the 16 week intervention |
| Mobility | 25ft walk test | At baseline and after the 16 week intervention |
| Blood markers of cardiovascular disease risk | blood lipid panel, HbA1c, fasting glucose | At baseline and after the 16 week intervention |
| Kingston |
| Ontario |
| K7L 3N6 |
| Canada |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D001519 | Behavior |