Evaluate Retention Rate of Topiramate, Levetiracetam and Oxcarbazepine in a Long-term Epilepsy Treatment

A Retrospective Study to Evaluate Retention Rate of Topiramate With That of Levetiracetam and Oxcarbazepine in a Long-term Epilepsy Treatment

The Objective of this study is to compare 2-year retention rate of topiramate, levetiracetam and oxcarbazepine in a long term epilepsy treatment.

Primary objective The Objective of this study is to compare 2-year retention rate of topiramate, levetiracetam and oxcarbazepine in a long term epilepsy treatment.

Secondary objective The main secondary objective of this study is to evaluate confounding factors associated with retention rate of topiramate compared with other anticonvulsants.

1. Baseline characteristics

   • Seizure Type
   • Gender
   • Age of onset

2. Treatment regimen

   • Number of concomitant medication
   • Type of drug combination
   • Final target dose
   • Titration speed

Other secondary objectives

The other secondary objectives of this study are to compare followings by each medication:

• Rate of seizure reduction (≥75%, ≥50%)
• Rate of seizure freedom

Inclusion Criteria:

• Subjects who began their treatment with topiramate, levetiracetam or oxcarbazepine as mono or add-on therapy with conventional drugs.
• Subjects who are with partial or generalized epilepsy

Exclusion Criteria:

• Subjects who administered combination therapy in topiramate, levetiracetam or oxcarbazepine
• Subjects who have past experience of surgery for epilepsy treatment
• Subjects who were not followed up for at least 1 year