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The present study aims to :
Despite impressive results in laboratory settings, there has been a significant lag in the community adoption and sustainability of family interventions for early-onset mood and psychotic disorders. Our objective is to determine the optimal methods of training and monitoring the delivery of an evidence-based family-focused treatment (FFT) in community providers who treat young patients (ages 13-25) with bipolar disorder (BD), psychosis, or "high-risk" conditions. FFT is administered in 12 sessions of psychoeducation, communication training, and problem-solving skills training. There are six randomized controlled trials indicating that, among adults or adolescents with BD, bipolar spectrum, or psychosis-risk disorders, FFT and pharmacotherapy are associated with more rapid stabilization of symptoms, delayed recurrences, enhanced functioning, better medication adherence, and improvements in family interaction relative to comparison treatments over 1-2 years. Using a community partnered participatory approach, we will engage diverse stakeholders (clinicians, administrators, caregivers) at three community sites (Harbor-UCLA Medical Center, San Fernando Mental Health Center, Didi Hirsch Mental Health Center) that treat early-onset, lower socioeconomic status, urban, and racially and ethnically diverse bipolar and psychosis patients. We will partner with these 3 community sites to randomly assign 30 clinicians to low intensity (web-based training plus low intensity supervision) or high intensity training (live workshop and higher intensity supervision, i.e., weekly individual supervision with fidelity feedback). Clinicians will administer FFT to up to 120 patients (ages 13-25) with recent-onset mania, psychosis or high-risk conditions. We expect that 20 clinicians will complete the treatment with 80 patients. Dependent variables will be empirically-derived fidelity component scores over time as measured by supervisors and clinicians. We hypothesize that after training, clinicians in both the high and low intensity groups will attain minimum levels of fidelity required for certification in the four components. However, clinicians in high intensity training will sustain higher levels of fidelity across subsequent treatment cases, and will be more satisfied and more likely to adopt the FFT model. This study will facilitate the translation of an evidence-based intervention and identify effective treatment components to inform larger-scale dissemination of FFT in community settings.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High Intensity Training | Experimental | High intensity training: clinician attends a 6-hr live workshop in family-focused treatment techniques, and then, after taking on a case, gets weekly technical consultation sessions (by telephone) in FFT from an expert after every session; |
|
| Low Intensity Training | Active Comparator | Low Intensity Training: clinician completes online workshop in FFT and then, after taking on a case, gets telephone consultation sessions after every third session. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High Intensity Training | Behavioral | This is a training method involving a live workshop followed by high intensity technical consultation. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Therapist Competency and Adherence Rating | This is a measure of how well the clinician administered family-focused treatment (FFT) based on ratings of audiotapes of family intervention sessions. These ratings are made every third session in both training conditions. This is an overall rating that can vary from 1 (nonadherent) to 7 (excellent adherence) | One year |
| Measure | Description | Time Frame |
|---|---|---|
| Patient Health Questionnaire, 9 | Self-rating of depression and impairment, administered at baseline, 4 months, and 12 months | 1 year |
| Young Mania Rating Scale | Mania symptoms (based on observer report) at baseline, 4 months and 12 months |
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Inclusion Criteria:
For patient participants:
Youth (13-17 years of age) and young adults (18-25 years of age) with the following:
Inclusion criteria for family clinicians:
Exclusion Criteria for patients:
Exclusion criteria for clinicians: none.
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| Name | Affiliation | Role |
|---|---|---|
| David J Miklowitz, Ph.D. | UCLA Semel Institute | Principal Investigator |
| Bowen Chung, M.D. | Harbor/UCLA Outpatient Psychiatry Program | Study Director |
| Ira Lesser, M.D. | Harbor/UCLA Outpatient Psychiatry Program | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Didi Hirsch Mental Health Services | Culver City | California | 90230 | United States | ||
| San Fernando Mental Health Center |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23357439 | Background | Miklowitz DJ, Schneck CD, Singh MK, Taylor DO, George EL, Cosgrove VE, Howe ME, Dickinson LM, Garber J, Chang KD. Early intervention for symptomatic youth at risk for bipolar disorder: a randomized trial of family-focused therapy. J Am Acad Child Adolesc Psychiatry. 2013 Feb;52(2):121-31. doi: 10.1016/j.jaac.2012.10.007. Epub 2013 Jan 2. | |
| 33779991 | Derived | Miklowitz DJ, Weintraub MJ, Posta F, Denenny DM, Chung B. Effects of High- versus Low-Intensity Clinician Training on Implementation of Family-Focused Therapy for Youth with Mood and Psychotic Disorders. Fam Process. 2021 Sep;60(3):727-740. doi: 10.1111/famp.12646. Epub 2021 Mar 29. |
| Label | URL |
|---|---|
| UCLA Child and Adolescent Mood Disorders Program | View source |
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| ID | Term |
|---|---|
| D019964 | Mood Disorders |
| D011618 | Psychotic Disorders |
| D001714 | Bipolar Disorder |
| ID | Term |
|---|---|
| D001523 | Mental Disorders |
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D000068105 | Bipolar and Related Disorders |
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| ID | Term |
|---|---|
| D000072696 | High-Intensity Interval Training |
| ID | Term |
|---|---|
| D064797 | Physical Conditioning, Human |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
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| Low Intensity Training | Behavioral | Clinicians complete an online workshop in family-focused therapy, followed by technical consultation sessions after every third session. |
|
| 1 year |
| Granada Hills |
| California |
| 91344 |
| United States |
| Harbor/UCLA Outpatient Psychiatry Porgram | Torrance | California | 90502 | United States |
| D009142 |
| Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |