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The study hypothesis is whether digestion enzyme(Combizym) and intestinal flora drugs(Bifidobacteria) can decease recurrence rate of colon polyps
Colon polyps has high recurrence rate in the digestion diseases. However, the reasons are not clear. The possible reasons for the recurrence of colon polyps include intestinal inflammation (e.g., Ulcerative colitis), intestinal flora imbalance (the benefit intestinal bacteria reduced, which lead to diarrhea or constipation), long-term indigestion. The investigators propose to examine whether digestion enzyme (Combizym) and intestinal flora drugs(Bifidobacteria) can decease recurrence rate of colon polyps
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Combizym-treated group | Active Comparator | The patients who received polypectomy of colon polyps take the digestion enzyme (Combizym) regularly. |
|
| Bifidobacteri-treated group | Active Comparator | The patients who received polypectomy of colon polyps take Bifidobacteri regularly |
|
| Combizym + Bifidobacteri-treated group | Active Comparator | The patients who received polypectomy of colon polyps take drugs (Combizym + Bifidobacteri) regularly |
|
| control | No Intervention | The patients who received polypectomy of colon polyps take no drugs |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Combizym | Drug | Combizym( 1 tablet, po, tid) |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| recurrence of colon polyps | The whole patients need be examined by colonoscopy one year later. The recurrence rate of colon polyps will be acquired in different arms | one year |
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Inclusion Criteria:
-Patients who have cutted colon polyps in one month, and the diagnosis were proved by pathological analysis
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Shengliang Chen | RenJi Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Renji Hospital | Shanghai | Shanghai Municipality | China |
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| ID | Term |
|---|---|
| D003111 | Colonic Polyps |
| ID | Term |
|---|---|
| D007417 | Intestinal Polyps |
| D011127 | Polyps |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| C005335 | Combizym |
| D010194 | Pancreatin |
| ID | Term |
|---|---|
| D006867 | Hydrolases |
| D004798 | Enzymes |
| D045762 | Enzymes and Coenzymes |
| D010184 | Pancreatic Extracts |
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| Bifidobacteri | Drug | Bifidobacteri (2 tablet, po, tid) |
|
|
| Combizym + Bifidobacteri | Drug | Combizym( 1 tablet, po, tid) + Bifidobacteri (2 tablet, po, tid) |
|
|
| D014020 |
| Tissue Extracts |
| D045424 | Complex Mixtures |