This study is a phase I clinical trial for evaluating the pharmacokinetics and safety/tolerability of DA-7218 in healthy male volunteers.

Inclusion Criteria:

• Healthy male Korean 19-45 years
• Body weight:55-90kg, BMI:18.0-27.0

Exclusion Criteria:

• Present condition or history of any clinically significant disease
• Clinical evidence or history of GI disease or history of GI surgery
• History of hypersensitivities, including drug allergies
• AST (SGOT) or ALT (SGPT) > 1.5 times the upper normal limit
• Systolic blood pressure : <100 mmHg or >160 mmHg
• Diastolic blood pressure : <60 mmHg or >100 mmHg
• Drug abuse within 2 months, or a positive reaction to an abusive drug or cotinine
• Taken any ETC or herbal supplement within 2 weeks or any OTC or vitamin supplement within 1 week
• Participation in and administration of IP of another clinical trial within 2 months
• Donation of whole blood within 2 months, or blood components within 1 month, or receipt of blood transfusion within 1 month
• Consumption of more than 21 units of alcohol/week or inability to abstain from drinking during the study period
• Smoking within 3 months
• Taking caffeine- or grapefruit-containing products within 3 days
• Plan to be pregnant, or not to use an appropriate method of contraception