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The purpose of this study is to determine Fractional exhaled Nitric-Oxide (FeNO)levels and blood cytokines during acute bronchiolitis, and to seek for correlation between these markers and future development of asthma.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| RSV | Infant with acute bronchiolitis due to RSV | ||
| Co- Infection | Infant with acute bronchiolitis due to RSV and other respiratory virus | ||
| Other | Infant with acute bronchiolitis due to non-RSV respiratory virus | ||
| Unknown | Infant with acute bronchiolitis with negative PCR results for respiratory viruses | ||
| Control | Healthy infants |
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| Measure | Description | Time Frame |
|---|---|---|
| Physician diagnosed asthma | Modification of The International Study of Asthma and Allergies in Childhood (ISAAC) questionnaires | At the age of 4 years |
| Measure | Description | Time Frame |
|---|---|---|
| Fractional exhaled Nitric Oxide (FENO) level | FeNO level measured by a rapid-response chemiluminescence analyzer (Eco Physics CLD88 NO analyzer, EcoMedics AG,Switzerland). | During acute bronchiolitis, after 2 and 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Wheezing episode | From recruitment time till the age 4. | |
| PCR for respiratory viruses | Polymerase chain reaction (PCR) analysis of nasal secretion for: RSV, Influenza A, Influenza B, Pandemic H1N1, Adenovirus, human metapneumovirus (hMPV), Parainfluenza 1-3, Enterovirus, Bocavirus, Rhinovirus, Corona virus-229E, Corona-OC43, Corona-HKU1 and Corona-NL63. |
Inclusion Criteria:
Exclusion Criteria:
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Children ages 2 weeks to 2 years who will arrive to Dana Children's hospital, Tel-Aviv Medical Center due to first episode of shortness of breath and working diagnosis of bronchiolitis.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yakov Sivan, Professor | Contact | sivan@tlvmc.gov.il |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sourasky Medical Center | Recruiting | Tel Aviv | Israel |
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| ID | Term |
|---|---|
| D001988 | Bronchiolitis |
| D001249 | Asthma |
| D012135 | Respiratory Sounds |
| ID | Term |
|---|---|
| D001991 | Bronchitis |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D001982 | Bronchial Diseases |
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blood
| At recruitment |
| D012140 |
| Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012130 | Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |