Black Cohosh Extract for Treatment of Moderate to Severe Menopausal Symptoms

Black Cohosh Extract for the Treatment of Moderate to Severe Menopausal Symptoms: a Randomized-placebo Controlled Trial

Compare the treatment efficacy of black cohosh extract 80 mg daily and placebo for moderate to severe menopausal symptoms

Compare the treatment efficacy of black cohosh extract 80 mg/day an placebo for moderate to severe menopausal symptoms with Kupperman menopausal index and MENQOL

Inclusion Criteria:

• Age at least 40 years
• Peri or post menopause
• Moderate to severe menopausal symptoms (Kupperman index at least 20)

Exclusion Criteria:

• Use hormonal treatment or other treatments within 4 weeks
• Use atorvastatin azathioprine or cyclosporin within 4 weeks
• BMI at least 30 kg m2
• Allergic to drug or components
• Liver disease or abnormal liver function test
• Psychiatric disease
• Alcoholic or drug abuse
• Vegetarian