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This prospective, open-label, single arm, non-interventional study will investigate the effectiveness of bevacizumab monotherapy in participants with lung adenocarcinoma who previously received 4 to 6 cycles of induction platinum doublet plus bevacizumab.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Bevacizumab | Participants who have received the induction phase of 4-6 cycles of bevacizumab plus platinum doublet chemotherapy will be treated with bevacizumab as maintenance treatment, according to approved label and local reimbursement. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Bevacizumab | Drug | Participants will receive bevacizumab 7.5 milligrams per kilograms (mg/kg) intravenously according to bevacizumab summary of product characteristics/local labeling. |
| Measure | Description | Time Frame |
|---|---|---|
| Progression-Free Survival (PFS), Defined as Time From First Dose of Maintenance Avastin Treatment Until Disease progression or death from any cause | Baseline up to 40 months |
| Measure | Description | Time Frame |
|---|---|---|
| PFS, defined as time from first dose of induction Avastin treatment until disease progression or death from any cause | Baseline up to 40 months | |
| 1-year overall survival defined as time from first dose of induction Avastin treatment until death from any cause |
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Inclusion Criteria:
Exclusion Criteria:
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Patients receiving Avastin monotherapy as maintenance treatment
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| Name | Affiliation | Role |
|---|---|---|
| Clinical Trials | Hoffmann-La Roche | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Orszagos Koranyi TBC es Pulmonologiai Intezet | Budapest | 1121 | Hungary | |||
| Semmelweis Egyetem X; Pulmonologiai Klinika |
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|
| 12 months |
| Percentage of participants by best overall response | Baseline up to 40 months |
| Percentage of participants with adverse events | Baseline up to 40 months |
| Budapest |
| 1125 |
| Hungary |
| Uzsoki Utcai Korhaz | Budapest | 1145 | Hungary |
| Debreceni Egyetem, Klinikai Kozpont, Tudogyogyaszati Klinika | Debrecen | 4032 | Hungary |
| Csongrad Megyei Mellkasi Betegsegek Szakkorhaza | Deszk | 6772 | Hungary |
| Veszprem Megyei Onkormanyzat Tudogyogyintezet | Farkasgyepű | 8582 | Hungary |
| Petz Aladar Megyei Oktato Korhaz | Győr | 9024 | Hungary |
| Bekes Megyei Tudokorhaz; I. Tudobelosztaly | Gyula | 5703 | Hungary |
| Bacs-Kiskun Megyei Korhaz | Kecskemét | 6000 | Hungary |
| Matrai Gyogyintezet | Mátraháza | 3233 | Hungary |
| Szabolcs-Szatmar-Bereg County Josa Andras Hospital; 1St Depatment of Pulmonary Medicine | Nyíregyháza | 4400 | Hungary |
| University of Pecs; 1St Department of Medicine | Pécs | 7623 | Hungary |
| Fejer Megyei Szent Gyorgy Korhaz | Székesfehérvár | 8000 | Hungary |
| Vas Megyei Markusovszky Korhaz ; Oncoradiology | Szombathely | 9700 | Hungary |
| Komárom-Esztergom Megyei; Szent Borbála Kórháza | Tatabánya | 2800 | Hungary |
| Tudogyogyintezet Torokbalint | Törökbálint | 2045 | Hungary |
| ID | Term |
|---|---|
| D000077192 | Adenocarcinoma of Lung |
| ID | Term |
|---|---|
| D000230 | Adenocarcinoma |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D008175 | Lung Neoplasms |
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
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| ID | Term |
|---|---|
| D000068258 | Bevacizumab |
| ID | Term |
|---|---|
| D061067 | Antibodies, Monoclonal, Humanized |
| D000911 | Antibodies, Monoclonal |
| D000906 | Antibodies |
| D007136 | Immunoglobulins |
| D007162 | Immunoproteins |
| D001798 | Blood Proteins |
| D011506 | Proteins |
| D000602 | Amino Acids, Peptides, and Proteins |
| D012712 | Serum Globulins |
| D005916 | Globulins |
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