The Link Between Obesity And Vitamin D in Bariatric Patients With Omega-loop Bypass Surgery

The Link Between Obesity And Vitamin D in Bariatric Patients With Omega-loop Bypass Surgery: a Randomized Controlled, Double-blinded Clinical Supplementation Trial

The aim of the study is to increase vitamin D concentrations or to keep it on high level, respectively, by supplementing with vitamin D3 in a different dose regime, and to improve the overall health status in bariatric patients. In this project, the vitamin D status, the parameters of inflammation, bone turnover, insulin resistance, liver and depression score of bariatric patients are expected to improve, due to supplementation of a loading dose compared to the standard therapy.

Inclusion Criteria:

• Planned omega loop bypass surgery
• 25-hydroxy vitamin D < 75 nmol/l
• BMI >40 or ≥35 kg/m2 with co-morbidities e.g. diabetes mellitus, hypertension
• Body weight <140 kg (due to limitation of DEXA measurement)
• Capability to consent

Exclusion Criteria:

• Another planned form of bariatric surgery
• Hypercalcemia (calcium >2.63 mmol/l) or hypocalcemia (<1.75 mmol/l)
• Renal insufficiency (creatinine >133 μmol/l or GFR <50 ml/min)
• Primary hyperparathyroidism
• Malignancy
• Infection e.g. human immunodeficiency virus
• Medical conditions requiring daily calcium supplements or antacid use
• Known hypersensitivity to cholecalciferol
• No capability to consent
• Imprisoned persons