Prophylaxis Of Wound Infections- Antibiotics in Renal Donation

Are Prophylactic Antibiotics Necessary Before Laparoscopic Living Kidney Donation? A Double Blind, Randomised, Controlled Trial.

The aim of this study is to see whether antibiotics given at the start of laparoscopic kidney donation surgery prevent infection.

Subjects undergoing laparoscopic donor nephrectomy will be randomised to either a single dose of intravenous co-amoxiclav or placebo prior to surgery. Outcome measures include any infections, length of stay and costs

Inclusion Criteria:

• All adult patients (over 18 years) undergoing hand-assisted laparoscopic donor nephrectomy, who have given written informed consent, will be included.
• Patients whose first language is not English will be included; they comprise a significant part of our patient population and we will use translation services as is our normal practice.
• Women of child-bearing age taking adequate contraception will be included.

Exclusion Criteria:

• Patients with a known allergy to penicillin or other antibiotics.
• Patients with MRSA colonisation.
• Participation in another investigational study within the previous 90 days.
• Pregnant or breast-feeding women.