The Safety and Efficacy of an Enzyme Combination in Managing Knee Osteoarthritis Pain in Adults

The Safety and Efficacy of an Enzyme Combination in Managing Knee Osteoarthritis Pain in Adults: a Randomized, Double-blind, Placebo-controlled Trial.

The aim of this randomized, double-blind, placebo-controlled, comparator-controlled trial was to evaluate the safety and efficacy of an enzyme combination, as Wobenzym®, in adults with moderate-to-severe osteoarthritis (OA) of the knee.

Inclusion Criteria:

• Knee osteoarthritis confirmed by radiography or tomography
• Lequesne Functional Index score of 10-14
• WOMAC-A pain subscale score greater than or equal to 25

Exclusion Criteria:

• History of knee trauma
• History of joint infection
• History of joint surgery
• History of intra-articular injection (viscotherapy)
• History of gastrointestinal diseases
• Use of corticosteroids
• Use of COX-II inhibitors
• Use of glucosamine/chondroitin
• Known sensitivity to paracetamol
• Known sensitivity to non-steroidal anti-inflammatory drugs (NSAIDs)
• Known sensitivity to oral enzymes